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MRI phenotype is associated with response to doxorubicin and cyclophosphamide neoadjuvant chemotherapy in stage III breast cancer.

Publication ,  Journal Article
Esserman, L; Kaplan, E; Partridge, S; Tripathy, D; Rugo, H; Park, J; Hwang, S; Kuerer, H; Sudilovsky, D; Lu, Y; Hylton, N
Published in: Ann Surg Oncol
July 2001

BACKGROUND: The preferred management for women with stage II or locally advanced breast cancer (LABC) is neoadjuvant chemotherapy. Pathologic response to chemotherapy has been shown to be an excellent predictor of outcome. Surrogates that can predict pathologic response and outcome will fuel future changes in management. Magnetic resonance imaging (MRI) demonstrates that patients with LABC have distinct tumor patterns. We investigated whether or not these patterns predict response to therapy. METHODS: Thirty-three women who received neoadjuvant doxorubicin and cyclophosphamide chemotherapy for 4 cycles and serial breast MRI scans before and after therapy were evaluated for this study. Response to therapy was measured by change in the longest diameter on the MRI. RESULTS: Five distinct imaging patterns were identified: circumscribed mass, nodular tissue infiltration diffuse tissue infiltration, patchy enhancement, and septal spread. The likelihood of a partial or complete response as measured by change in longest diameter was 77%, 37.5%, 20%, and 25%, respectively. CONCLUSIONS: MRI affords three-dimensional characterization of tumors and has revealed distinct patterns of tumor presentation that predict response. A multisite trial is being planned to combine imaging and genetic information in an effort to better understand and predict response and, ultimately, to tailor therapy and direct the use of novel agents.

Duke Scholars

Published In

Ann Surg Oncol

DOI

ISSN

1068-9265

Publication Date

July 2001

Volume

8

Issue

6

Start / End Page

549 / 559

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Predictive Value of Tests
  • Phenotype
  • Patient Selection
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Neoadjuvant Therapy
  • Middle Aged
  • Magnetic Resonance Imaging
  • Humans
 

Citation

APA
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Esserman, L., Kaplan, E., Partridge, S., Tripathy, D., Rugo, H., Park, J., … Hylton, N. (2001). MRI phenotype is associated with response to doxorubicin and cyclophosphamide neoadjuvant chemotherapy in stage III breast cancer. Ann Surg Oncol, 8(6), 549–559. https://doi.org/10.1007/s10434-001-0549-8
Esserman, L., E. Kaplan, S. Partridge, D. Tripathy, H. Rugo, J. Park, S. Hwang, et al. “MRI phenotype is associated with response to doxorubicin and cyclophosphamide neoadjuvant chemotherapy in stage III breast cancer.Ann Surg Oncol 8, no. 6 (July 2001): 549–59. https://doi.org/10.1007/s10434-001-0549-8.
Esserman L, Kaplan E, Partridge S, Tripathy D, Rugo H, Park J, et al. MRI phenotype is associated with response to doxorubicin and cyclophosphamide neoadjuvant chemotherapy in stage III breast cancer. Ann Surg Oncol. 2001 Jul;8(6):549–59.
Esserman, L., et al. “MRI phenotype is associated with response to doxorubicin and cyclophosphamide neoadjuvant chemotherapy in stage III breast cancer.Ann Surg Oncol, vol. 8, no. 6, July 2001, pp. 549–59. Pubmed, doi:10.1007/s10434-001-0549-8.
Esserman L, Kaplan E, Partridge S, Tripathy D, Rugo H, Park J, Hwang S, Kuerer H, Sudilovsky D, Lu Y, Hylton N. MRI phenotype is associated with response to doxorubicin and cyclophosphamide neoadjuvant chemotherapy in stage III breast cancer. Ann Surg Oncol. 2001 Jul;8(6):549–559.
Journal cover image

Published In

Ann Surg Oncol

DOI

ISSN

1068-9265

Publication Date

July 2001

Volume

8

Issue

6

Start / End Page

549 / 559

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Predictive Value of Tests
  • Phenotype
  • Patient Selection
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Neoadjuvant Therapy
  • Middle Aged
  • Magnetic Resonance Imaging
  • Humans