Systemic oxidative stress, as measured by urinary allantoin and F(2)-isoprostanes, is not increased in Down syndrome.

Journal Article (Journal Article)

PURPOSE: Oxidative stress has been implicated in Down syndrome (DS) pathology. This study compares DS individuals and controls on their urinary levels of allantoin and 2,3-dinor-iPF2α-III; these biomarkers have been previously validated in a clinical model of oxidative stress. METHODS: Urine samples were collected from 48 individuals with DS and 130 controls. Biomarkers were assayed by ultraperformance liquid chromatography-tandem mass spectrometry, normalized by urinary creatinine concentration. RESULTS: After adjusting for age and gender, mean allantoin levels were lower among DS individuals versus controls (P = .04). The adjusted mean levels of 2,3-dinor-iPF2α-III were similar in DS individuals and controls (P = .7). CONCLUSIONS: Our results do not support the hypothesis that DS individuals have chronic systemic oxidative stress.

Full Text

Duke Authors

Cited Authors

  • Tolun, AA; Scarbrough, PM; Zhang, H; McKillop, J-A; Wang, F; Kishnani, PS; Millington, DS; Young, SP; Il'yasova, D

Published Date

  • December 2012

Published In

Volume / Issue

  • 22 / 12

Start / End Page

  • 892 - 894

PubMed ID

  • 23063134

Pubmed Central ID

  • PMC3508197

Electronic International Standard Serial Number (EISSN)

  • 1873-2585

Digital Object Identifier (DOI)

  • 10.1016/j.annepidem.2012.09.005


  • eng

Conference Location

  • United States