Systemic oxidative stress, as measured by urinary allantoin and F(2)-isoprostanes, is not increased in Down syndrome.
Journal Article (Journal Article)
PURPOSE: Oxidative stress has been implicated in Down syndrome (DS) pathology. This study compares DS individuals and controls on their urinary levels of allantoin and 2,3-dinor-iPF2α-III; these biomarkers have been previously validated in a clinical model of oxidative stress. METHODS: Urine samples were collected from 48 individuals with DS and 130 controls. Biomarkers were assayed by ultraperformance liquid chromatography-tandem mass spectrometry, normalized by urinary creatinine concentration. RESULTS: After adjusting for age and gender, mean allantoin levels were lower among DS individuals versus controls (P = .04). The adjusted mean levels of 2,3-dinor-iPF2α-III were similar in DS individuals and controls (P = .7). CONCLUSIONS: Our results do not support the hypothesis that DS individuals have chronic systemic oxidative stress.
Full Text
Duke Authors
Cited Authors
- Tolun, AA; Scarbrough, PM; Zhang, H; McKillop, J-A; Wang, F; Kishnani, PS; Millington, DS; Young, SP; Il'yasova, D
Published Date
- December 2012
Published In
Volume / Issue
- 22 / 12
Start / End Page
- 892 - 894
PubMed ID
- 23063134
Pubmed Central ID
- PMC3508197
Electronic International Standard Serial Number (EISSN)
- 1873-2585
Digital Object Identifier (DOI)
- 10.1016/j.annepidem.2012.09.005
Language
- eng
Conference Location
- United States