ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium.

Published

Journal Article

PURPOSE:Previous studies have examined the association between ABO blood group and ovarian cancer risk, with inconclusive results. METHODS:In eight studies participating in the Ovarian Cancer Association Consortium, we determined ABO blood groups and diplotypes by genotyping 3 SNPs in the ABO locus. Odds ratios and 95 % confidence intervals were calculated in each study using logistic regression; individual study results were combined using random effects meta-analysis. RESULTS:Compared to blood group O, the A blood group was associated with a modestly increased ovarian cancer risk: (OR: 1.09; 95 % CI: 1.01-1.18; p = 0.03). In diplotype analysis, the AO, but not the AA diplotype, was associated with increased risk (AO: OR: 1.11; 95 % CI: 1.01-1.22; p = 0.03; AA: OR: 1.03; 95 % CI: 0.87-1.21; p = 0.76). Neither AB nor the B blood groups were associated with risk. Results were similar across ovarian cancer histologic subtypes. CONCLUSION:Consistent with most previous reports, the A blood type was associated modestly with increased ovarian cancer risk in this large analysis of multiple studies of ovarian cancer. Future studies investigating potential biologic mechanisms are warranted.

Full Text

Duke Authors

Cited Authors

  • Poole, EM; Gates, MA; High, BA; Chanock, SJ; Cramer, DW; Cunningham, JM; Fridley, BL; Gayther, SA; Goode, EL; Iversen, ES; Lissowska, J; Palmieri Weber, RT; Pharoah, PDP; Phelan, CM; Ramus, SJ; Schildkraut, JM; Sutphen, R; Tsai, Y-Y; Tyrer, J; Vierkant, RA; Wentzensen, N; Yang, HP; Terry, KL; Tworoger, SS

Published Date

  • November 2012

Published In

Volume / Issue

  • 23 / 11

Start / End Page

  • 1805 - 1810

PubMed ID

  • 22961099

Pubmed Central ID

  • 22961099

Electronic International Standard Serial Number (EISSN)

  • 1573-7225

International Standard Serial Number (ISSN)

  • 0957-5243

Digital Object Identifier (DOI)

  • 10.1007/s10552-012-0059-y

Language

  • eng