Fourier domain pump-probe optical coherence tomography: Hemoglobin imaging at 830 nm


Journal Article

The detailed 3-D mapping of tissue microcirculation, including blood oxygen saturation and flow, would provide important biometrics needed to understand the cause and progression of numerous diseases. To that end we have started developing a two-color Fourier domain Pump-Probe Optical Coherence Tomography (PPOCT) system designed specifically to image hemoglobin with the eventual goal of measuring blood oxygen saturation. This system utilizes a two-color pump-probe scheme chosen to maximize the potential imaging depth by probing in the near IR where the tissue scattering properties are most favorable and pumping in the visible where the hemoglobin light absorption is most efficient. A sample consisting of pure hemoglobin placed between two coverslips has been used for the initial demonstration and to begin the process of optimizing the system.

Full Text

Duke Authors

Cited Authors

  • Applegate, BE; Jacob, D; Izatt, JA

Published Date

  • April 21, 2008

Published In

Volume / Issue

  • 6847 /

International Standard Serial Number (ISSN)

  • 1605-7422

Digital Object Identifier (DOI)

  • 10.1117/12.766839

Citation Source

  • Scopus