Spectral domain second-harmonic optical coherence tomography.
Journal Article (Journal Article)
Optical coherence tomography (OCT) provides micrometer-scale structural imaging by coherent detection of backscattered light. Molecular contrast in OCT has been demonstrated using transient absorption, coherent anti-Stokes Raman scattering, and second-harmonic (SH) generation. The sensitivity of molecular contrast signals can be enhanced by use of Fourier domain techniques. We have constructed a spectrometer-based Fourier domain SH-OCT system for simultaneous acquisition of the fundamental and SH signals. We report a >30 dB increase in SH sensitivity over a similar time domain SH-OCT system and demonstrate contrast between cartilage and bone using collagen as the contrast agent.
Full Text
Duke Authors
Cited Authors
- Sarunic, MV; Applegate, BE; Izatt, JA
Published Date
- September 2005
Published In
Volume / Issue
- 30 / 18
Start / End Page
- 2391 - 2393
PubMed ID
- 16196329
Electronic International Standard Serial Number (EISSN)
- 1539-4794
International Standard Serial Number (ISSN)
- 0146-9592
Digital Object Identifier (DOI)
- 10.1364/ol.30.002391
Language
- eng