Spectral domain second-harmonic optical coherence tomography.

Journal Article (Journal Article)

Optical coherence tomography (OCT) provides micrometer-scale structural imaging by coherent detection of backscattered light. Molecular contrast in OCT has been demonstrated using transient absorption, coherent anti-Stokes Raman scattering, and second-harmonic (SH) generation. The sensitivity of molecular contrast signals can be enhanced by use of Fourier domain techniques. We have constructed a spectrometer-based Fourier domain SH-OCT system for simultaneous acquisition of the fundamental and SH signals. We report a >30 dB increase in SH sensitivity over a similar time domain SH-OCT system and demonstrate contrast between cartilage and bone using collagen as the contrast agent.

Full Text

Duke Authors

Cited Authors

  • Sarunic, MV; Applegate, BE; Izatt, JA

Published Date

  • September 2005

Published In

Volume / Issue

  • 30 / 18

Start / End Page

  • 2391 - 2393

PubMed ID

  • 16196329

Electronic International Standard Serial Number (EISSN)

  • 1539-4794

International Standard Serial Number (ISSN)

  • 0146-9592

Digital Object Identifier (DOI)

  • 10.1364/ol.30.002391


  • eng