Investigating pulsed dye laser-blood vessel interaction with color Doppler optical coherence tomography.


Journal Article

A non-invasive method of imaging laser irradiated blood vessels has been achieved using Color Doppler Optical Coherence Tomography (CDOCT). This method may increase understanding of the mechanisms behind treatment of vascular disorders. The CDOCT system used a 1280 nm center wavelength superluminescent diode. A 585 nm, 360 aes pulsed dye laser was used to irradiate hamster dorsal skin flap window preparations. Irradiation sites were imaged with CDOCT prior to, immediately after, and 24 hours after laser irradiation. The processed CDOCT signal provided an estimate of the blood flow velocity. An increase in the blood vessel backscattered signal was observed as blood or vessel walls were coagulated. A decrease in damaged blood vessel reflectivity occurred after twenty four hours.

Full Text

Duke Authors

Cited Authors

  • Barton, J; Welch, A; Izatt, J

Published Date

  • September 1998

Published In

Volume / Issue

  • 3 / 6

Start / End Page

  • 251 - 256

PubMed ID

  • 19384367

Pubmed Central ID

  • 19384367

Electronic International Standard Serial Number (EISSN)

  • 1094-4087

International Standard Serial Number (ISSN)

  • 1094-4087

Digital Object Identifier (DOI)

  • 10.1364/oe.3.000251


  • eng