Therapy for ocular toxoplasmosis.

Journal Article (Journal Article;Review)

PURPOSE: To review current evidence for the treatment of ocular toxoplasmosis (OT). DESIGN: Narrative review and expert recommendations. METHODS: Meta-analysis and selected original articles from the medical literature were reviewed critically. Expert recommendations were analyzed. RESULTS: Numerous observational studies suggest a benefit of short-term antimicrobial therapy for toxoplasmic retinochoroiditis in immunocompetent patients, although its efficacy has not been proven in randomized clinical trials. A randomized clinical trial revealed that intermittent trimethoprim/sulfamethoxazole treatment could decrease the rate of recurrence in high-risk patients. Intravitreal injection of clindamycin and dexamethasone was an acceptable alternative to the classic treatment for OT in a randomized clinical trial. CONCLUSIONS: Opinions about therapy differ and controversy remains about its type, efficacy, and length. Intravitreal therapy may be promising for OT. A recent description of the presence of parasitemia in patients with active and inactive ocular toxoplasmosis raises new questions that need to be explored.

Full Text

Duke Authors

Cited Authors

  • de-la-Torre, A; Stanford, M; Curi, A; Jaffe, GJ; Gomez-Marin, JE

Published Date

  • October 2011

Published In

Volume / Issue

  • 19 / 5

Start / End Page

  • 314 - 320

PubMed ID

  • 21970662

Electronic International Standard Serial Number (EISSN)

  • 1744-5078

Digital Object Identifier (DOI)

  • 10.3109/09273948.2011.608915


  • eng

Conference Location

  • England