Therapy for ocular toxoplasmosis.
Journal Article (Journal Article;Review)
PURPOSE: To review current evidence for the treatment of ocular toxoplasmosis (OT). DESIGN: Narrative review and expert recommendations. METHODS: Meta-analysis and selected original articles from the medical literature were reviewed critically. Expert recommendations were analyzed. RESULTS: Numerous observational studies suggest a benefit of short-term antimicrobial therapy for toxoplasmic retinochoroiditis in immunocompetent patients, although its efficacy has not been proven in randomized clinical trials. A randomized clinical trial revealed that intermittent trimethoprim/sulfamethoxazole treatment could decrease the rate of recurrence in high-risk patients. Intravitreal injection of clindamycin and dexamethasone was an acceptable alternative to the classic treatment for OT in a randomized clinical trial. CONCLUSIONS: Opinions about therapy differ and controversy remains about its type, efficacy, and length. Intravitreal therapy may be promising for OT. A recent description of the presence of parasitemia in patients with active and inactive ocular toxoplasmosis raises new questions that need to be explored.
Full Text
Duke Authors
Cited Authors
- de-la-Torre, A; Stanford, M; Curi, A; Jaffe, GJ; Gomez-Marin, JE
Published Date
- October 2011
Published In
Volume / Issue
- 19 / 5
Start / End Page
- 314 - 320
PubMed ID
- 21970662
Electronic International Standard Serial Number (EISSN)
- 1744-5078
Digital Object Identifier (DOI)
- 10.3109/09273948.2011.608915
Language
- eng
Conference Location
- England