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Increased incidence of sterile endophthalmitis after intravitreal triamcinolone acetonide in spring 2006.

Publication ,  Journal Article
Stepien, KE; Eaton, AM; Jaffe, GJ; Davis, JL; Raja, J; Feuer, W
Published in: Retina
February 2009

PURPOSE: To compare the incidence of sterile endophthalmitis after intravitreal triamcinolone acetonide injections during a 6 month period in 2006 to the same period in 2005 and determine the incidence after switching to intravitreal preservative-free triamcinolone acetonide. METHODS: Retrospective multicenter interventional case series in which patients receiving intravitreal triamcinolone acetonide at three institutions from March 2005 to August 2005 and from March 2006 to August 2006 and intravitreal preservative-free triamcinolone acetonide from late summer 2006 through February 2007 were reviewed for the development of sterile endophthalmitis. RESULTS: From March 2005 to August 2005, the rate of sterile endophthalmitis was 0% at all institutions. From March 2006 to August 2006, a statistically significant increase in sterile endophthalmitis was seen at all institutions with frequencies of 3.5% to 6.3% (P < 0.001). With transition to preservative-free triamcinolone acetonide, sterile endophthalmitis over the next 6 months decreased to 0% at two sites and to 2.5% (from 5.5%) at the third institution (P < 0.009). CONCLUSIONS: A statistically significant increase in the rate of sterile endophthalmitis after intravitreal triamcinolone acetonide was seen in a 6 month period in 2006 when compared with the same period in 2005. Transition to preservative-free triamcinolone acetonide produced a frequency of sterile endophthalmitis similar to 2005.

Duke Scholars

Published In

Retina

DOI

EISSN

1539-2864

Publication Date

February 2009

Volume

29

Issue

2

Start / End Page

207 / 213

Location

United States

Related Subject Headings

  • Vitreous Body
  • Triamcinolone Acetonide
  • Time Factors
  • Seasons
  • Risk Factors
  • Retrospective Studies
  • Preservatives, Pharmaceutical
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Stepien, K. E., Eaton, A. M., Jaffe, G. J., Davis, J. L., Raja, J., & Feuer, W. (2009). Increased incidence of sterile endophthalmitis after intravitreal triamcinolone acetonide in spring 2006. Retina, 29(2), 207–213. https://doi.org/10.1097/IAE.0b013e31818eccb3
Stepien, Kimberly E., Alexander M. Eaton, Glenn J. Jaffe, Janet L. Davis, Junaid Raja, and William Feuer. “Increased incidence of sterile endophthalmitis after intravitreal triamcinolone acetonide in spring 2006.Retina 29, no. 2 (February 2009): 207–13. https://doi.org/10.1097/IAE.0b013e31818eccb3.
Stepien KE, Eaton AM, Jaffe GJ, Davis JL, Raja J, Feuer W. Increased incidence of sterile endophthalmitis after intravitreal triamcinolone acetonide in spring 2006. Retina. 2009 Feb;29(2):207–13.
Stepien, Kimberly E., et al. “Increased incidence of sterile endophthalmitis after intravitreal triamcinolone acetonide in spring 2006.Retina, vol. 29, no. 2, Feb. 2009, pp. 207–13. Pubmed, doi:10.1097/IAE.0b013e31818eccb3.
Stepien KE, Eaton AM, Jaffe GJ, Davis JL, Raja J, Feuer W. Increased incidence of sterile endophthalmitis after intravitreal triamcinolone acetonide in spring 2006. Retina. 2009 Feb;29(2):207–213.

Published In

Retina

DOI

EISSN

1539-2864

Publication Date

February 2009

Volume

29

Issue

2

Start / End Page

207 / 213

Location

United States

Related Subject Headings

  • Vitreous Body
  • Triamcinolone Acetonide
  • Time Factors
  • Seasons
  • Risk Factors
  • Retrospective Studies
  • Preservatives, Pharmaceutical
  • Ophthalmology & Optometry
  • Middle Aged
  • Male