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Intraocular pressure in patients with uveitis treated with fluocinolone acetonide implants.

Publication ,  Journal Article
Goldstein, DA; Godfrey, DG; Hall, A; Callanan, DG; Jaffe, GJ; Pearson, PA; Usner, DW; Comstock, TL
Published in: Arch Ophthalmol
November 2007

OBJECTIVE: To report the incidence and management of elevated intraocular pressure (IOP) in patients with uveitis treated with the fluocinolone acetonide (FA) intravitreal implant. DESIGN: Pooled data from 3 multicenter, double-masked, randomized, controlled, phase 2b/3 clinical trials evaluating the safety and efficacy of the 0.59-mg or 2.1-mg FA intravitreal implant or standard therapy were analyzed. RESULTS: During the 3-year follow-up, 71.0% of implanted eyes had an IOP increase of 10 mm Hg or more than baseline and 55.1%, 24.7%, and 6.2% of eyes reached an IOP of 30 mm Hg or more, 40 mm Hg or more, and 50 mm Hg or more, respectively. Topical IOP-lowering medication was administered in 74.8% of implanted eyes, and IOP-lowering surgeries, most of which were trabeculectomies (76.2%), were performed on 36.6% of implanted eyes. Intraocular pressure-lowering surgeries were considered a success (postoperative IOP of 6-21 mm Hg with or without additional IOP-lowering medication) in 85.1% of eyes at 1 year. The rate of hypotony (IOP

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Published In

Arch Ophthalmol

DOI

ISSN

0003-9950

Publication Date

November 2007

Volume

125

Issue

11

Start / End Page

1478 / 1485

Location

United States

Related Subject Headings

  • Uveitis
  • Treatment Outcome
  • Trabeculectomy
  • Time Factors
  • Randomized Controlled Trials as Topic
  • Ophthalmology & Optometry
  • Ocular Hypertension
  • Multicenter Studies as Topic
  • Middle Aged
  • Male
 

Citation

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Goldstein, D. A., Godfrey, D. G., Hall, A., Callanan, D. G., Jaffe, G. J., Pearson, P. A., … Comstock, T. L. (2007). Intraocular pressure in patients with uveitis treated with fluocinolone acetonide implants. Arch Ophthalmol, 125(11), 1478–1485. https://doi.org/10.1001/archopht.125.11.ecs70063
Goldstein, Debra A., David G. Godfrey, Anthony Hall, David G. Callanan, Glenn J. Jaffe, P Andrew Pearson, Dale W. Usner, and Timothy L. Comstock. “Intraocular pressure in patients with uveitis treated with fluocinolone acetonide implants.Arch Ophthalmol 125, no. 11 (November 2007): 1478–85. https://doi.org/10.1001/archopht.125.11.ecs70063.
Goldstein DA, Godfrey DG, Hall A, Callanan DG, Jaffe GJ, Pearson PA, et al. Intraocular pressure in patients with uveitis treated with fluocinolone acetonide implants. Arch Ophthalmol. 2007 Nov;125(11):1478–85.
Goldstein, Debra A., et al. “Intraocular pressure in patients with uveitis treated with fluocinolone acetonide implants.Arch Ophthalmol, vol. 125, no. 11, Nov. 2007, pp. 1478–85. Pubmed, doi:10.1001/archopht.125.11.ecs70063.
Goldstein DA, Godfrey DG, Hall A, Callanan DG, Jaffe GJ, Pearson PA, Usner DW, Comstock TL. Intraocular pressure in patients with uveitis treated with fluocinolone acetonide implants. Arch Ophthalmol. 2007 Nov;125(11):1478–1485.

Published In

Arch Ophthalmol

DOI

ISSN

0003-9950

Publication Date

November 2007

Volume

125

Issue

11

Start / End Page

1478 / 1485

Location

United States

Related Subject Headings

  • Uveitis
  • Treatment Outcome
  • Trabeculectomy
  • Time Factors
  • Randomized Controlled Trials as Topic
  • Ophthalmology & Optometry
  • Ocular Hypertension
  • Multicenter Studies as Topic
  • Middle Aged
  • Male