Intraocular pressure in patients with uveitis treated with fluocinolone acetonide implants.
OBJECTIVE: To report the incidence and management of elevated intraocular pressure (IOP) in patients with uveitis treated with the fluocinolone acetonide (FA) intravitreal implant. DESIGN: Pooled data from 3 multicenter, double-masked, randomized, controlled, phase 2b/3 clinical trials evaluating the safety and efficacy of the 0.59-mg or 2.1-mg FA intravitreal implant or standard therapy were analyzed. RESULTS: During the 3-year follow-up, 71.0% of implanted eyes had an IOP increase of 10 mm Hg or more than baseline and 55.1%, 24.7%, and 6.2% of eyes reached an IOP of 30 mm Hg or more, 40 mm Hg or more, and 50 mm Hg or more, respectively. Topical IOP-lowering medication was administered in 74.8% of implanted eyes, and IOP-lowering surgeries, most of which were trabeculectomies (76.2%), were performed on 36.6% of implanted eyes. Intraocular pressure-lowering surgeries were considered a success (postoperative IOP of 6-21 mm Hg with or without additional IOP-lowering medication) in 85.1% of eyes at 1 year. The rate of hypotony (IOP
Duke Scholars
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Related Subject Headings
- Uveitis
- Treatment Outcome
- Trabeculectomy
- Time Factors
- Randomized Controlled Trials as Topic
- Ophthalmology & Optometry
- Ocular Hypertension
- Multicenter Studies as Topic
- Middle Aged
- Male
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Uveitis
- Treatment Outcome
- Trabeculectomy
- Time Factors
- Randomized Controlled Trials as Topic
- Ophthalmology & Optometry
- Ocular Hypertension
- Multicenter Studies as Topic
- Middle Aged
- Male