Toll-like receptor 7 mediates pruritus.

Journal Article (Journal Article)

Toll-like receptors are typically expressed in immune cells to regulate innate immunity. We found that functional Toll-like receptor 7 (TLR7) was expressed in C-fiber primary sensory neurons and was important for inducing itch (pruritus), but was not necessary for eliciting mechanical, thermal, inflammatory and neuropathic pain in mice. Our results indicate that TLR7 mediates itching and is a potential therapeutic target for anti-itch treatment in skin disease conditions.

Full Text

Duke Authors

Cited Authors

  • Liu, T; Xu, Z-Z; Park, C-K; Berta, T; Ji, R-R

Published Date

  • December 2010

Published In

Volume / Issue

  • 13 / 12

Start / End Page

  • 1460 - 1462

PubMed ID

  • 21037581

Pubmed Central ID

  • PMC2991508

Electronic International Standard Serial Number (EISSN)

  • 1546-1726

Digital Object Identifier (DOI)

  • 10.1038/nn.2683


  • eng

Conference Location

  • United States