Matrix metalloprotease regulation of neuropathic pain.

Journal Article (Journal Article)

Neuropathic pain affects millions of people globally and could be a disease on its own right. Current treatments focus on blocking neurotransmission and have resulted in limited success. Recent progress points to an important role of neuroinflammation in the pathogenesis of neuropathic pain. Matrix metalloproteases (MMPs) comprise a large family of zinc endopeptidases that have been implicated in the generation of neuroinflammation via cleavage of extracellular matrix proteins and activation of proinflammatory cytokines and chemokines. However, little is known about the role of MMPs in chronic pain regulation. Our recent study has shown that neuropathic pain development in the early and late phase requires MMP-9 and MMP-2, respectively. Inhibition of MMP-9 or MMP-2 might provide a new strategy for the prevention and treatment of neuropathic pain.

Full Text

Duke Authors

Cited Authors

  • Ji, R-R; Xu, Z-Z; Wang, X; Lo, EH

Published Date

  • July 2009

Published In

Volume / Issue

  • 30 / 7

Start / End Page

  • 336 - 340

PubMed ID

  • 19523695

Pubmed Central ID

  • PMC2706286

Electronic International Standard Serial Number (EISSN)

  • 1873-3735

Digital Object Identifier (DOI)

  • 10.1016/


  • eng

Conference Location

  • England