Repetitive transcranial magnetic stimulation activates specific regions in rat brain.


Journal Article

Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive technique to induce electric currents in the brain. Although rTMS is being evaluated as a possible alternative to electroconvulsive therapy for the treatment of refractory depression, little is known about the pattern of activation induced in the brain by rTMS. We have compared immediate early gene expression in rat brain after rTMS and electroconvulsive stimulation, a well-established animal model for electroconvulsive therapy. Our result shows that rTMS applied in conditions effective in animal models of depression induces different patterns of immediate-early gene expression than does electroconvulsive stimulation. In particular, rTMS evokes strong neural responses in the paraventricular nucleus of the thalamus (PVT) and in other regions involved in the regulation of circadian rhythms. The response in PVT is independent of the orientation of the stimulation probe relative to the head. Part of this response is likely because of direct activation, as repetitive magnetic stimulation also activates PVT neurons in brain slices.

Full Text

Duke Authors

Cited Authors

  • Ji, RR; Schlaepfer, TE; Aizenman, CD; Epstein, CM; Qiu, D; Huang, JC; Rupp, F

Published Date

  • December 22, 1998

Published In

Volume / Issue

  • 95 / 26

Start / End Page

  • 15635 - 15640

PubMed ID

  • 9861022

Pubmed Central ID

  • 9861022

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.95.26.15635


  • eng

Conference Location

  • United States