Use of Antifungal Combination Therapy: Agents, Order, and Timing.


Journal Article

Given the substantial morbidity and mortality related to invasive fungal infections, treatment with a combination of antifungal agents is often considered. A growing body of literature from in vitro studies, animal models, and clinical experience provides data evaluating this approach. This review describes combination antifungal strategies for the management of cryptococcal meningitis, invasive candidiasis, invasive aspergillosis, and rare mold infections. The potential effects that sequencing and timing have on the efficacy of such approaches are discussed, with a focus on recent clinical data in this arena.

Full Text

Duke Authors

Cited Authors

  • Johnson, MD; Perfect, JR

Published Date

  • May 1, 2010

Published In

Volume / Issue

  • 4 / 2

Start / End Page

  • 87 - 95

PubMed ID

  • 20574543

Pubmed Central ID

  • 20574543

International Standard Serial Number (ISSN)

  • 1936-3761

Digital Object Identifier (DOI)

  • 10.1007/s12281-010-0018-6


  • eng

Conference Location

  • United States