Translating genomics into clinical practice: applications in lung cancer.

Journal Article (Journal Article;Review)

Non-small cell lung cancer (NSCLC) is the leading cause of death from cancer worldwide and has a poor overall survival across all stages of disease. The recent advancement of gene expression technology addresses the phenotypic complexity of many diseases, including NSCLC. These genomic approaches have shown great promise in NSCLC in helping to improve risk stratification, prognosis, and the clinician's ability to match the right therapy to an individual patient. Large prospective clinical trials are under way to evaluate the application and clinical impact of the use of genomics-based predictors of prognosis and therapy compared with current standard-of-care methods in patients with NSCLC. Several challenges of genomics-based therapy must be addressed before widespread application of these techniques becomes a reality. Genomic approaches in NSCLC have the potential to advance our understanding of underlying disease biology, to improve current prognostic and treatment paradigms, and to identify new targets for treatment, ultimately improving survival in patients with NSCLC and providing an opportunity for "personalized medicine."

Full Text

Duke Authors

Cited Authors

  • Jolly Graham, A; Potti, A

Published Date

  • July 2009

Published In

Volume / Issue

  • 11 / 4

Start / End Page

  • 263 - 268

PubMed ID

  • 19508830

Electronic International Standard Serial Number (EISSN)

  • 1534-6269

Digital Object Identifier (DOI)

  • 10.1007/s11912-009-0037-z


  • eng

Conference Location

  • United States