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Epidermal growth factor receptor gene amplification and protein expression in glioblastoma multiforme: prognostic significance and relationship to other prognostic factors.

Publication ,  Journal Article
Layfield, LJ; Willmore, C; Tripp, S; Jones, C; Jensen, RL
Published in: Appl Immunohistochem Mol Morphol
March 2006

Epidermal growth factor receptor (EGFR) overexpression occurs in a significant percentage of cases of glioblastoma multiforme (GBM), and amplification has been found in approximately 40% of these neoplasms. Controversy exists as to the prognostic significance of EGFR gene amplification: some reports have indicated that amplification is associated with a poor prognosis, while other authors have reported no relationship between gene amplification and prognosis. Some reports have found a poor prognosis to be associated with amplification of the EGFR gene in patients of all ages with GBM, while other authors have found EGFR amplification to be an independent predictor of prolonged survival in patients with GBM who are older than 60 years of age. The authors studied a series of 34 specimens (32 patients) with histologically proven GBM by immunohistochemistry for the presence of EGFR overexpression and by fluorescence in situ hybridization (FISH) for gene amplification of the EGFR gene. Results of these studies and data on patient age, sex, functional status, therapy, and survival were correlated to determine which variables were predictive of survival. p53 expression was also determined by immunohistochemistry and correlated with the other variables and survival.

Duke Scholars

Published In

Appl Immunohistochem Mol Morphol

DOI

ISSN

1541-2016

Publication Date

March 2006

Volume

14

Issue

1

Start / End Page

91 / 96

Location

United States

Related Subject Headings

  • Tumor Suppressor Protein p53
  • Survival Analysis
  • Prognosis
  • Pathology
  • Middle Aged
  • Male
  • In Situ Hybridization, Fluorescence
  • Immunohistochemistry
  • Humans
  • Glioblastoma
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Layfield, L. J., Willmore, C., Tripp, S., Jones, C., & Jensen, R. L. (2006). Epidermal growth factor receptor gene amplification and protein expression in glioblastoma multiforme: prognostic significance and relationship to other prognostic factors. Appl Immunohistochem Mol Morphol, 14(1), 91–96. https://doi.org/10.1097/01.pai.0000159772.73775.2e
Layfield, Lester J., Carlynn Willmore, Sheryl Tripp, Claudia Jones, and Randy L. Jensen. “Epidermal growth factor receptor gene amplification and protein expression in glioblastoma multiforme: prognostic significance and relationship to other prognostic factors.Appl Immunohistochem Mol Morphol 14, no. 1 (March 2006): 91–96. https://doi.org/10.1097/01.pai.0000159772.73775.2e.
Layfield, Lester J., et al. “Epidermal growth factor receptor gene amplification and protein expression in glioblastoma multiforme: prognostic significance and relationship to other prognostic factors.Appl Immunohistochem Mol Morphol, vol. 14, no. 1, Mar. 2006, pp. 91–96. Pubmed, doi:10.1097/01.pai.0000159772.73775.2e.

Published In

Appl Immunohistochem Mol Morphol

DOI

ISSN

1541-2016

Publication Date

March 2006

Volume

14

Issue

1

Start / End Page

91 / 96

Location

United States

Related Subject Headings

  • Tumor Suppressor Protein p53
  • Survival Analysis
  • Prognosis
  • Pathology
  • Middle Aged
  • Male
  • In Situ Hybridization, Fluorescence
  • Immunohistochemistry
  • Humans
  • Glioblastoma