Splenectomy for Felty's syndrome. Clinicopathological study of 27 patients.

Published

Journal Article

The major clinical and pathological features and the long-term follow-up of 27 patients with Felty's syndrome who were treated with splenectomy for sever granulocytpenia and for acute, chronic, or recurrent infection were studied. Granulocyte counts rose within days in most patients, although slow responses and transient granulocytopenia did occur; only 12% of the patients had persistent or recurrent granulocytopenia. Infections resolved promptly in 77% of the patients, more slowly in the remainder, and only one patient had new problems of infection after aplenectomy. Splenic enlargement, present in all but one case, was attributable to expansion of the sinusoidal pulp. The most substantial pathological features of immune stimulation included germinal center hyperplasia and prominent clusters of plasma and preplasma cells within sinuses.

Full Text

Duke Authors

Cited Authors

  • Laszlo, J; Jones, R; Silberman, HR; Banks, PM

Published Date

  • April 1, 1978

Published In

Volume / Issue

  • 138 / 4

Start / End Page

  • 597 - 602

PubMed ID

  • 637640

Pubmed Central ID

  • 637640

Electronic International Standard Serial Number (EISSN)

  • 1538-3679

International Standard Serial Number (ISSN)

  • 0003-9926

Digital Object Identifier (DOI)

  • 10.1001/archinte.1978.03630280059020

Language

  • eng