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Effects of time, dose, and inversion time for acute myocardial infarct size measurements based on magnetic resonance imaging-delayed contrast enhancement.

Publication ,  Journal Article
Wagner, A; Mahrholdt, H; Thomson, L; Hager, S; Meinhardt, G; Rehwald, W; Parker, M; Shah, D; Sechtem, U; Kim, RJ; Judd, RM
Published in: J Am Coll Cardiol
May 16, 2006

OBJECTIVES: This study sought to investigate the influence of time, dose, and inversion time (TI) and their interactions on myocardial infarct size measurements to establish the foundation for a standardized protocol for multicenter trials. BACKGROUND: There is growing interest in using magnetic resonance imaging (MRI) infarct size measurements as an end point in clinical trials. However, no standardized protocol exists, and there are limited data concerning the effects of time, contrast agent dose, and TI. METHODS: First, we determined the influence of postcontrast imaging time (5 to 40 min), contrast agent dose (0.1 vs. 0.2 mmol/kg), TI, and their interactions in an animal model (n = 14). Second, we tested whether the findings of the animal study apply to patients and are generalizable. Therefore, we retested the diagnostic window in a multicenter study. A total of 48 patients with first acute myocardial infarction (AMI) from three centers were imaged twice (5 and 30 min) after injection of 0.15 mmol/kg gadolinium diethylenetriamine-pentaacetate using an adjusted TI. RESULTS: The animal study showed that the infarct size is independent of time and dose (p = 0.9 and p = 0.16, respectively) using an adjusted TI. Using a fixed TI, however, infarct size is a function of time and dose (p = 0.0001 and p = 0.01, respectively). The multicenter study showed that MRI 1 (16.9 +/- 12% of left ventricle) was not statistically different from MRI 2 (16.4 +/- 12% of left ventricle, p = NS) with no difference between sites (p = NS). CONCLUSIONS: The AMI size can be measured with MRI using a contrast dose between 0.1 and 0.2 mmol/kg and a time window of 5 to 30 min after contrast administration, provided that the TI is adjusted.

Duke Scholars

Published In

J Am Coll Cardiol

DOI

EISSN

1558-3597

Publication Date

May 16, 2006

Volume

47

Issue

10

Start / End Page

2027 / 2033

Location

United States

Related Subject Headings

  • Time Factors
  • Risk Assessment
  • Prospective Studies
  • Myocardial Infarction
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Gadolinium DTPA
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Wagner, A., Mahrholdt, H., Thomson, L., Hager, S., Meinhardt, G., Rehwald, W., … Judd, R. M. (2006). Effects of time, dose, and inversion time for acute myocardial infarct size measurements based on magnetic resonance imaging-delayed contrast enhancement. J Am Coll Cardiol, 47(10), 2027–2033. https://doi.org/10.1016/j.jacc.2006.01.059
Wagner, Anja, Heiko Mahrholdt, Louise Thomson, Stefan Hager, Gabriel Meinhardt, Wolfgang Rehwald, Michele Parker, et al. “Effects of time, dose, and inversion time for acute myocardial infarct size measurements based on magnetic resonance imaging-delayed contrast enhancement.J Am Coll Cardiol 47, no. 10 (May 16, 2006): 2027–33. https://doi.org/10.1016/j.jacc.2006.01.059.
Wagner A, Mahrholdt H, Thomson L, Hager S, Meinhardt G, Rehwald W, et al. Effects of time, dose, and inversion time for acute myocardial infarct size measurements based on magnetic resonance imaging-delayed contrast enhancement. J Am Coll Cardiol. 2006 May 16;47(10):2027–33.
Wagner, Anja, et al. “Effects of time, dose, and inversion time for acute myocardial infarct size measurements based on magnetic resonance imaging-delayed contrast enhancement.J Am Coll Cardiol, vol. 47, no. 10, May 2006, pp. 2027–33. Pubmed, doi:10.1016/j.jacc.2006.01.059.
Wagner A, Mahrholdt H, Thomson L, Hager S, Meinhardt G, Rehwald W, Parker M, Shah D, Sechtem U, Kim RJ, Judd RM. Effects of time, dose, and inversion time for acute myocardial infarct size measurements based on magnetic resonance imaging-delayed contrast enhancement. J Am Coll Cardiol. 2006 May 16;47(10):2027–2033.
Journal cover image

Published In

J Am Coll Cardiol

DOI

EISSN

1558-3597

Publication Date

May 16, 2006

Volume

47

Issue

10

Start / End Page

2027 / 2033

Location

United States

Related Subject Headings

  • Time Factors
  • Risk Assessment
  • Prospective Studies
  • Myocardial Infarction
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Gadolinium DTPA
  • Female