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Effects of myocardial water exchange on T1 enhancement during bolus administration of MR contrast agents.

Publication ,  Journal Article
Judd, RM; Atalay, MK; Rottman, GA; Zerhouni, EA
Published in: Magn Reson Med
February 1995

Interpretation of first-pass myocardial perfusion studies employing bolus administration of T1 magnetic resonance (MR) contrast agents requires an understanding of the relationship between contrast concentration and image pixel intensity. The potential effects of myocardial water exchange rates among the intravascular, interstitial, and cellular compartments on this relationship are controversial. We directly studied these issues in isolated, nonbeating canine interventricular septa. Myocardial T1 was measured three times/s during bolus transit of intravascular (albumin-Gd-DTPA and polylysine-Gd-DTPA) and extracellular (gadoteridol) contrast agents. For polylysine-Gd-DTPA, the peak changes in myocardial 1/T1 (delta R1) scaled nonlinearly with perfusate contrast concentration whereas a linear relationship would be expected for fast water exchange among the vascular, interstitial, and cellular compartments. For all agents, the peak delta R1 were much smaller than the values expected on the basis of fast myocardial water exchange. The data demonstrate that in isolated myocardial tissue, myocardial T1 enhancement during bolus administration of contrast can be strongly affected by myocardial water exchange for both intravascular and extracellular MR contrast agents.

Duke Scholars

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

February 1995

Volume

33

Issue

2

Start / End Page

215 / 223

Location

United States

Related Subject Headings

  • Time Factors
  • Reproducibility of Results
  • Protons
  • Polylysine
  • Pentetic Acid
  • Organometallic Compounds
  • Nuclear Medicine & Medical Imaging
  • Myocardium
  • Magnetic Resonance Imaging
  • Image Enhancement
 

Citation

APA
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MLA
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Judd, R. M., Atalay, M. K., Rottman, G. A., & Zerhouni, E. A. (1995). Effects of myocardial water exchange on T1 enhancement during bolus administration of MR contrast agents. Magn Reson Med, 33(2), 215–223. https://doi.org/10.1002/mrm.1910330211
Judd, R. M., M. K. Atalay, G. A. Rottman, and E. A. Zerhouni. “Effects of myocardial water exchange on T1 enhancement during bolus administration of MR contrast agents.Magn Reson Med 33, no. 2 (February 1995): 215–23. https://doi.org/10.1002/mrm.1910330211.
Judd RM, Atalay MK, Rottman GA, Zerhouni EA. Effects of myocardial water exchange on T1 enhancement during bolus administration of MR contrast agents. Magn Reson Med. 1995 Feb;33(2):215–23.
Judd, R. M., et al. “Effects of myocardial water exchange on T1 enhancement during bolus administration of MR contrast agents.Magn Reson Med, vol. 33, no. 2, Feb. 1995, pp. 215–23. Pubmed, doi:10.1002/mrm.1910330211.
Judd RM, Atalay MK, Rottman GA, Zerhouni EA. Effects of myocardial water exchange on T1 enhancement during bolus administration of MR contrast agents. Magn Reson Med. 1995 Feb;33(2):215–223.
Journal cover image

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

February 1995

Volume

33

Issue

2

Start / End Page

215 / 223

Location

United States

Related Subject Headings

  • Time Factors
  • Reproducibility of Results
  • Protons
  • Polylysine
  • Pentetic Acid
  • Organometallic Compounds
  • Nuclear Medicine & Medical Imaging
  • Myocardium
  • Magnetic Resonance Imaging
  • Image Enhancement