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Rapid measurements of diastolic intramyocardial vascular volume.

Publication ,  Journal Article
Judd, RM; Resar, JR; Yin, FC
Published in: Am J Physiol
October 1993

Rapid measurements of coronary vascular volume are necessary for a complete understanding of phasic coronary flow. Because no standard method is capable of making these measurements, we developed a method that uses digital subtraction angiography to image an intravascular contrast agent. The method is capable of measuring vascular volume in 33 ms and can be repeated three times per second. The method was first validated in phantoms. We then used this method to measure coronary vascular volume in the isolated, perfluorochemical-perfused, interventricular canine septum. The speed of the measurements allowed us, for the first time, to directly measure transients in vascular volume following sudden changes in perfusion pressure. At the steady-state and maximal vasodilation, coronary vascular volume varied from 7.5 +/- 1.2 (SE) ml/100 g at a perfusion pressure of 20 mmHg to 12.1 +/- 1.9 ml/100 g at 90 mmHg, which is similar to other reports. After a sudden change of 40 mmHg in perfusion pressure, vascular volume changed with a time constant of 3.2 +/- 0.3 (SE) s. Increasing ventricular wall stretch had no effect on either the steady-state volumes (P = 0.25) or the time constant for volume changes (P = 0.17). The fact that the time constant is longer than the cardiac cycle, yet much shorter than the time necessary to measure vascular volume using other methods, highlights the need for rapid measurements of vascular volume.

Duke Scholars

Published In

Am J Physiol

DOI

ISSN

0002-9513

Publication Date

October 1993

Volume

265

Issue

4 Pt 2

Start / End Page

H1038 / H1047

Location

United States

Related Subject Headings

  • Serum Albumin
  • Iodine Radioisotopes
  • In Vitro Techniques
  • Dogs
  • Diastole
  • Coronary Circulation
  • Contrast Media
  • Cardiovascular System & Hematology
  • Blood Volume
  • Animals
 

Citation

APA
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ICMJE
MLA
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Judd, R. M., Resar, J. R., & Yin, F. C. (1993). Rapid measurements of diastolic intramyocardial vascular volume. Am J Physiol, 265(4 Pt 2), H1038–H1047. https://doi.org/10.1152/ajpheart.1993.265.4.H1038
Judd, R. M., J. R. Resar, and F. C. Yin. “Rapid measurements of diastolic intramyocardial vascular volume.Am J Physiol 265, no. 4 Pt 2 (October 1993): H1038–47. https://doi.org/10.1152/ajpheart.1993.265.4.H1038.
Judd RM, Resar JR, Yin FC. Rapid measurements of diastolic intramyocardial vascular volume. Am J Physiol. 1993 Oct;265(4 Pt 2):H1038–47.
Judd, R. M., et al. “Rapid measurements of diastolic intramyocardial vascular volume.Am J Physiol, vol. 265, no. 4 Pt 2, Oct. 1993, pp. H1038–47. Pubmed, doi:10.1152/ajpheart.1993.265.4.H1038.
Judd RM, Resar JR, Yin FC. Rapid measurements of diastolic intramyocardial vascular volume. Am J Physiol. 1993 Oct;265(4 Pt 2):H1038–H1047.

Published In

Am J Physiol

DOI

ISSN

0002-9513

Publication Date

October 1993

Volume

265

Issue

4 Pt 2

Start / End Page

H1038 / H1047

Location

United States

Related Subject Headings

  • Serum Albumin
  • Iodine Radioisotopes
  • In Vitro Techniques
  • Dogs
  • Diastole
  • Coronary Circulation
  • Contrast Media
  • Cardiovascular System & Hematology
  • Blood Volume
  • Animals