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Tone-dependent waterfall behavior during venous pressure elevation in isolated canine hearts.

Publication ,  Journal Article
Farhi, ER; Klocke, FJ; Mates, RE; Kumar, K; Judd, RM; Canty, JM; Satoh, S; Sekovski, B
Published in: Circ Res
February 1991

We examined the "vascular waterfall" hypothesis, which proposes that coronary flow is unaffected by elevations in outflow pressure until the latter reaches a critical threshold level, in 29 isolated canine hearts. In fibrillating hearts vasodilated with adenosine or carbocromen, coronary flow and the coronary pressure-flow relation were not affected by changes in great cardiac vein pressure (PGCV) below a threshold value of 11 +/- 0.9 (mean +/- SEM) mm Hg. Further elevations of PGCV reduced flow and shifted the pressure-flow relation to the right, increasing its pressure-axis intercept (Pf=0). When vasomotor tone was augmented with vasopressin, threshold PGCV increased to 25 +/- 2.7 mm Hg (p less than 0.001). Once again, the pressure-flow relation was unaffected by changes in PGCV below the threshold value and shifted to the right when this value was exceeded. The amount by which spontaneous values of Pf=0 exceeded threshold values of PGCV was greater when vasomotor tone was augmented than during vasodilation. Pf=0 continued to exceed PGCV when the latter was raised above the threshold level. Both Pf=0 and threshold values of PGCV were less during a long diastole than during ventricular fibrillation. We reached the following conclusions. 1) During changes in PGCV below a threshold value, the coronary circulation exhibits traditional waterfall behavior. 2) The threshold pressure for altering waterfall behavior is affected by vascular tone and mechanical activity. 3) Pf=0 remains above PGCV when the latter is increased above the threshold value needed to alter flow.

Duke Scholars

Published In

Circ Res

DOI

ISSN

0009-7330

Publication Date

February 1991

Volume

68

Issue

2

Start / End Page

392 / 401

Location

United States

Related Subject Headings

  • Venous Pressure
  • Muscle Tonus
  • Models, Cardiovascular
  • In Vitro Techniques
  • Dogs
  • Differential Threshold
  • Coronary Circulation
  • Cardiovascular System & Hematology
  • Animals
  • 3202 Clinical sciences
 

Citation

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Farhi, E. R., Klocke, F. J., Mates, R. E., Kumar, K., Judd, R. M., Canty, J. M., … Sekovski, B. (1991). Tone-dependent waterfall behavior during venous pressure elevation in isolated canine hearts. Circ Res, 68(2), 392–401. https://doi.org/10.1161/01.res.68.2.392
Farhi, E. R., F. J. Klocke, R. E. Mates, K. Kumar, R. M. Judd, J. M. Canty, S. Satoh, and B. Sekovski. “Tone-dependent waterfall behavior during venous pressure elevation in isolated canine hearts.Circ Res 68, no. 2 (February 1991): 392–401. https://doi.org/10.1161/01.res.68.2.392.
Farhi ER, Klocke FJ, Mates RE, Kumar K, Judd RM, Canty JM, et al. Tone-dependent waterfall behavior during venous pressure elevation in isolated canine hearts. Circ Res. 1991 Feb;68(2):392–401.
Farhi, E. R., et al. “Tone-dependent waterfall behavior during venous pressure elevation in isolated canine hearts.Circ Res, vol. 68, no. 2, Feb. 1991, pp. 392–401. Pubmed, doi:10.1161/01.res.68.2.392.
Farhi ER, Klocke FJ, Mates RE, Kumar K, Judd RM, Canty JM, Satoh S, Sekovski B. Tone-dependent waterfall behavior during venous pressure elevation in isolated canine hearts. Circ Res. 1991 Feb;68(2):392–401.

Published In

Circ Res

DOI

ISSN

0009-7330

Publication Date

February 1991

Volume

68

Issue

2

Start / End Page

392 / 401

Location

United States

Related Subject Headings

  • Venous Pressure
  • Muscle Tonus
  • Models, Cardiovascular
  • In Vitro Techniques
  • Dogs
  • Differential Threshold
  • Coronary Circulation
  • Cardiovascular System & Hematology
  • Animals
  • 3202 Clinical sciences