Evaluation of neuromuscular junction disorders in the electromyography laboratory.

Journal Article (Journal Article;Review)

Neuromuscular junction (NMJ) disorders may be demonstrated using repetitive nerve stimulation (RNS) testing and single-fiber electromyography (SFEMG). RNS testing with low frequency stimulation reduces the safety factor of neuromuscular transmission (NMT) and may elicit decrementing compound muscle action potential (CMAP) responses. Exercise or tetanic nerve stimulation may potentiate acetylcholine release in presynaptic NMT disorders with CMAP facilitation. SFEMG is a selective recording technique assessing MFAPs within the same motor unit. Jitter is increased in NMJ disorders, and is the temporal variability between these MFAPs. Impulse blocking reflects failure of NMT. RNS and SFEMG findings in NMJ disorders are reviewed.

Full Text

Duke Authors

Cited Authors

  • Juel, VC

Published Date

  • May 2012

Published In

Volume / Issue

  • 30 / 2

Start / End Page

  • 621 - 639

PubMed ID

  • 22361377

Electronic International Standard Serial Number (EISSN)

  • 1557-9875

Digital Object Identifier (DOI)

  • 10.1016/j.ncl.2011.12.012


  • eng

Conference Location

  • United States