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Mutational hotspots in the mitochondrial genome of lung cancer.

Publication ,  Journal Article
Choi, S-J; Kim, S-H; Kang, HY; Lee, J; Bhak, JH; Sohn, I; Jung, S-H; Choi, YS; Kim, HK; Han, J; Huh, N; Lee, G; Kim, BC; Kim, J
Published in: Biochem Biophys Res Commun
April 1, 2011

We determined the somatic mutations in the mitochondrial genomes of 70 lung cancer patients by pair-wise comparative analyses of the normal- and tumor-genome sequences acquired using Affymetrix Mitochondrial Resequencing Array 2.0. The overall mutation rates in lung cancers were Approximately 100 fold higher than those in normal cells, with significant statistical correlation with smoking (p=0.00088). Total of 532 somatic mutations were evenly distributed in 499 positions with very low overall frequency (1.07/bp), but the non-synonymous mutations causing amino acid substitution occurred more frequently (1.83/bp), particularly at two positions, 8701 and 10398 (10.5/bp) that code for ATPase6 and NADH dehydrogenase 3, respectively. Despite the randomness or even distribution of the mutations, these two mutations occurred together in 86% of the cases. The linkage between the two most frequent mutations suggests that they were selected together, possibly due to their cooperative role during cancer development. Indeed, the mutation at 10398 was shown by Canter, Pezzotti, and their colleagues in 2009, as a risk factor for breast cancer. In this study, we identified two potential biomarkers that might be functionally linked together during the development of cancer.

Duke Scholars

Published In

Biochem Biophys Res Commun

DOI

EISSN

1090-2104

Publication Date

April 1, 2011

Volume

407

Issue

1

Start / End Page

23 / 27

Location

United States

Related Subject Headings

  • Smoking
  • Republic of Korea
  • Polymorphism, Genetic
  • Mutagenesis
  • Mitochondrial Proton-Translocating ATPases
  • Male
  • Lung Neoplasms
  • Humans
  • Germ-Line Mutation
  • Genome, Mitochondrial
 

Citation

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Choi, S.-J., Kim, S.-H., Kang, H. Y., Lee, J., Bhak, J. H., Sohn, I., … Kim, J. (2011). Mutational hotspots in the mitochondrial genome of lung cancer. Biochem Biophys Res Commun, 407(1), 23–27. https://doi.org/10.1016/j.bbrc.2011.02.078
Choi, So-Jung, Sung-Hyun Kim, Ho Y. Kang, Jinseon Lee, Jong H. Bhak, Insuk Sohn, Sin-Ho Jung, et al. “Mutational hotspots in the mitochondrial genome of lung cancer.Biochem Biophys Res Commun 407, no. 1 (April 1, 2011): 23–27. https://doi.org/10.1016/j.bbrc.2011.02.078.
Choi S-J, Kim S-H, Kang HY, Lee J, Bhak JH, Sohn I, et al. Mutational hotspots in the mitochondrial genome of lung cancer. Biochem Biophys Res Commun. 2011 Apr 1;407(1):23–7.
Choi, So-Jung, et al. “Mutational hotspots in the mitochondrial genome of lung cancer.Biochem Biophys Res Commun, vol. 407, no. 1, Apr. 2011, pp. 23–27. Pubmed, doi:10.1016/j.bbrc.2011.02.078.
Choi S-J, Kim S-H, Kang HY, Lee J, Bhak JH, Sohn I, Jung S-H, Choi YS, Kim HK, Han J, Huh N, Lee G, Kim BC, Kim J. Mutational hotspots in the mitochondrial genome of lung cancer. Biochem Biophys Res Commun. 2011 Apr 1;407(1):23–27.
Journal cover image

Published In

Biochem Biophys Res Commun

DOI

EISSN

1090-2104

Publication Date

April 1, 2011

Volume

407

Issue

1

Start / End Page

23 / 27

Location

United States

Related Subject Headings

  • Smoking
  • Republic of Korea
  • Polymorphism, Genetic
  • Mutagenesis
  • Mitochondrial Proton-Translocating ATPases
  • Male
  • Lung Neoplasms
  • Humans
  • Germ-Line Mutation
  • Genome, Mitochondrial