Sample size computation for two-sample noninferiority log-rank test.

Journal Article (Journal Article)

When an experimental therapy is less extensive, less toxic, or less expensive than a standard therapy, we may want to prove that the former is not worse than the latter through a noninferiority trial. In this article, we discuss a modification of the log-rank test for noninferiority trials with survival endpoint and propose a sample size formula that can be used in designing such trials. Performance of our sample size formula is investigated through simulations. Our formula is applied to design a real clinical trial.

Full Text

Duke Authors

Cited Authors

  • Jung, S-H; Kang, SJ; McCall, LM; Blumenstein, B

Published Date

  • January 2005

Published In

Volume / Issue

  • 15 / 6

Start / End Page

  • 969 - 979

PubMed ID

  • 16279355

Electronic International Standard Serial Number (EISSN)

  • 1520-5711

International Standard Serial Number (ISSN)

  • 1054-3406

Digital Object Identifier (DOI)

  • 10.1080/10543400500265736


  • eng