Exercise-induced hypertension, endothelial dysfunction, and coronary artery disease in a marathon runner.


Journal Article

Aerobic activity performed on a regular basis is 1 of several lifestyle recommendations endorsed to reduce risk of coronary disease. However, 1 potential concern of arduous aerobic activity is exercise-induced hypertension. This is the first case to our knowledge, of accelerated coronary calcification in an otherwise asymptomatic middle-aged male marathon runner devoid of traditional cardiovascular risk factors. As a consequence of exercise-induced hypertension and associated oxidative stress, improvement of endothelial dysfunction occurred after antioxidant supplementation. In conclusion, vigorous aerobic activity in susceptible individuals may promote oxidative stress and coronary atherosclerosis.

Full Text

Duke Authors

Cited Authors

  • Goel, R; Majeed, F; Vogel, R; Corretti, MC; Weir, M; Mangano, C; White, C; Plotnick, GD; Miller, M

Published Date

  • March 2007

Published In

Volume / Issue

  • 99 / 5

Start / End Page

  • 743 - 744

PubMed ID

  • 17317385

Pubmed Central ID

  • 17317385

Electronic International Standard Serial Number (EISSN)

  • 1879-1913

International Standard Serial Number (ISSN)

  • 0002-9149

Digital Object Identifier (DOI)

  • 10.1016/j.amjcard.2006.09.127


  • eng