Metabolomics: a global biochemical approach to drug response and disease.

Published

Journal Article (Review)

Metabolomics is the study of metabolism at the global level. This rapidly developing new discipline has important potential implications for pharmacologic science. The concept that metabolic state is representative of the overall physiologic status of the organism lies at the heart of metabolomics. Metabolomic studies capture global biochemical events by assaying thousands of small molecules in cells, tissues, organs, or biological fluids-followed by the application of informatic techniques to define metabolomic signatures. Metabolomic studies can lead to enhanced understanding of disease mechanisms and to new diagnostic markers as well as enhanced understanding of mechanisms for drug or xenobiotic effect and increased ability to predict individual variation in drug response phenotypes (pharmacometabolomics). This review outlines the conceptual basis for metabolomics as well as analytical and informatic techniques used to study the metabolome and to define metabolomic signatures. It also highlights potential metabolomic applications to pharmacology and clinical pharmacology.

Full Text

Duke Authors

Cited Authors

  • Kaddurah-Daouk, R; Kristal, BS; Weinshilboum, RM

Published Date

  • January 2008

Published In

Volume / Issue

  • 48 /

Start / End Page

  • 653 - 683

PubMed ID

  • 18184107

Pubmed Central ID

  • 18184107

Electronic International Standard Serial Number (EISSN)

  • 1545-4304

International Standard Serial Number (ISSN)

  • 0362-1642

Digital Object Identifier (DOI)

  • 10.1146/annurev.pharmtox.48.113006.094715

Language

  • eng