Neuroprotective effects of creatine administration against NMDA and malonate toxicity.

Journal Article (Journal Article)

We examined whether creatine administration could exert neuroprotective effects against excitotoxicity mediated by N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainic acid. Oral administration of 1% creatine significantly attenuated striatal excitotoxic lesions produced by NMDA, but had no effect on lesions produced by AMPA or kainic acid. Both creatine and nicotinamide can exert significant protective effects against malonate-induced striatal lesions. We, therefore, examined whether nicotinamide could exert additive neuroprotective effects with creatine against malonate-induced lesions. Nicotinamide with creatine produced significantly better neuroprotection than creatine alone against malonate-induced lesions. Creatine can, therefore, produce significant neuroprotective effects against NMDA mediated excitotoxic lesions in vivo and the combination of nicotinamide with creatine exerts additive neuroprotective effects.

Full Text

Duke Authors

Cited Authors

  • Malcon, C; Kaddurah-Daouk, R; Beal, MF

Published Date

  • March 31, 2000

Published In

Volume / Issue

  • 860 / 1-2

Start / End Page

  • 195 - 198

PubMed ID

  • 10727643

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/s0006-8993(00)02038-2


  • eng

Conference Location

  • Netherlands