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The synthetic phosphagen cyclocreatine phosphate inhibits the growth of a broad spectrum of solid tumors.

Publication ,  Journal Article
Schimmel, L; Khandekar, VS; Martin, KJ; Riera, T; Honan, C; Shaw, DG; Kaddurah-Daouk, R
Published in: Anticancer Res
1996

BACKGROUND: The brain isoform of creatine kinase (CKBB), an enzyme involved in energy metabolism, has been implicated in cellular transformation process. Cyclocreatine (CCr), a creatine kinase (CK) substrate analogue, was shown to inhibit the growth of a broad spectrum of solid tumors expressing high levels of CK. Cyclocreatine phosphate (CCrP) generated by CK, was proposed to be the active form responsible for growth inhibition. MATERIALS AND METHODS: We synthesized CCrP and tested its cellular uptake and anti tumor activity in stem cell assays and in athymic mouse models. RESULTS: CCrP seems to be taken up by cells and inhibits the growth of solid tumors with high levels of CK. CCr and CCrP have similar specificity and potency. CONCLUSION: The observation that only high-CK cell lines were responsive to CCrP, similar to CCr, indicates that the enzyme requirement was not bypassed. We propose that CK is a target for CCrP, and is involved in mediating its antiproliferative activity.

Duke Scholars

Published In

Anticancer Res

ISSN

0250-7005

Publication Date

1996

Volume

16

Issue

1

Start / End Page

375 / 380

Location

Greece

Related Subject Headings

  • Tumor Cells, Cultured
  • Prostatic Neoplasms
  • Phosphocreatine
  • Oncology & Carcinogenesis
  • Neoplasms
  • Neoplasm Transplantation
  • Mice, Nude
  • Mice, Inbred BALB C
  • Mice
  • Male
 

Citation

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ICMJE
MLA
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Schimmel, L., Khandekar, V. S., Martin, K. J., Riera, T., Honan, C., Shaw, D. G., & Kaddurah-Daouk, R. (1996). The synthetic phosphagen cyclocreatine phosphate inhibits the growth of a broad spectrum of solid tumors. Anticancer Res, 16(1), 375–380.
Schimmel, L., V. S. Khandekar, K. J. Martin, T. Riera, C. Honan, D. G. Shaw, and R. Kaddurah-Daouk. “The synthetic phosphagen cyclocreatine phosphate inhibits the growth of a broad spectrum of solid tumors.Anticancer Res 16, no. 1 (1996): 375–80.
Schimmel L, Khandekar VS, Martin KJ, Riera T, Honan C, Shaw DG, et al. The synthetic phosphagen cyclocreatine phosphate inhibits the growth of a broad spectrum of solid tumors. Anticancer Res. 1996;16(1):375–80.
Schimmel, L., et al. “The synthetic phosphagen cyclocreatine phosphate inhibits the growth of a broad spectrum of solid tumors.Anticancer Res, vol. 16, no. 1, 1996, pp. 375–80.
Schimmel L, Khandekar VS, Martin KJ, Riera T, Honan C, Shaw DG, Kaddurah-Daouk R. The synthetic phosphagen cyclocreatine phosphate inhibits the growth of a broad spectrum of solid tumors. Anticancer Res. 1996;16(1):375–380.

Published In

Anticancer Res

ISSN

0250-7005

Publication Date

1996

Volume

16

Issue

1

Start / End Page

375 / 380

Location

Greece

Related Subject Headings

  • Tumor Cells, Cultured
  • Prostatic Neoplasms
  • Phosphocreatine
  • Oncology & Carcinogenesis
  • Neoplasms
  • Neoplasm Transplantation
  • Mice, Nude
  • Mice, Inbred BALB C
  • Mice
  • Male