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Antiproliferative effects of cyclocreatine on human prostatic carcinoma cells.

Publication ,  Journal Article
Hoosein, NM; Martin, KJ; Abdul, M; Logothetis, CJ; Kaddurah-Daouk, R
Published in: Anticancer Res
1995

Creatine kinase (CK; EC 2.7.3.2) isoenzymes and their substrates have an important function in cellular energy generation and utilization. The brain isoform (CK-BB) has been implicated in cellular transformation processes involving the oncogenic products of the Ela virus and the p53 tumor suppressor gene. Cyclocreatine, an analogue of creatine, has been previously shown to inhibit the growth of a broad spectrum of cancer cells derived from solid tumors. Results reported herein indicate an increased level of creatine kinase activity in human prostate carcinoma cell lines and inhibitory effects of cyclocreatine alone and in combination with adriamycin on the growth of these cells in vitro and in vivo, in immune-deprived mice. Our results suggest the possible use of cyclocreatine in the treatment of prostatic carcinoma.

Duke Scholars

Published In

Anticancer Res

ISSN

0250-7005

Publication Date

1995

Volume

15

Issue

4

Start / End Page

1339 / 1342

Location

Greece

Related Subject Headings

  • Tumor Cells, Cultured
  • Prostatic Neoplasms
  • Oncology & Carcinogenesis
  • Mice, Nude
  • Mice, Inbred BALB C
  • Mice
  • Male
  • Humans
  • Doxorubicin
  • Creatinine
 

Citation

APA
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ICMJE
MLA
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Hoosein, N. M., Martin, K. J., Abdul, M., Logothetis, C. J., & Kaddurah-Daouk, R. (1995). Antiproliferative effects of cyclocreatine on human prostatic carcinoma cells. Anticancer Res, 15(4), 1339–1342.
Hoosein, N. M., K. J. Martin, M. Abdul, C. J. Logothetis, and R. Kaddurah-Daouk. “Antiproliferative effects of cyclocreatine on human prostatic carcinoma cells.Anticancer Res 15, no. 4 (1995): 1339–42.
Hoosein NM, Martin KJ, Abdul M, Logothetis CJ, Kaddurah-Daouk R. Antiproliferative effects of cyclocreatine on human prostatic carcinoma cells. Anticancer Res. 1995;15(4):1339–42.
Hoosein, N. M., et al. “Antiproliferative effects of cyclocreatine on human prostatic carcinoma cells.Anticancer Res, vol. 15, no. 4, 1995, pp. 1339–42.
Hoosein NM, Martin KJ, Abdul M, Logothetis CJ, Kaddurah-Daouk R. Antiproliferative effects of cyclocreatine on human prostatic carcinoma cells. Anticancer Res. 1995;15(4):1339–1342.

Published In

Anticancer Res

ISSN

0250-7005

Publication Date

1995

Volume

15

Issue

4

Start / End Page

1339 / 1342

Location

Greece

Related Subject Headings

  • Tumor Cells, Cultured
  • Prostatic Neoplasms
  • Oncology & Carcinogenesis
  • Mice, Nude
  • Mice, Inbred BALB C
  • Mice
  • Male
  • Humans
  • Doxorubicin
  • Creatinine