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Microtubule stabilization and potentiation of taxol activity by the creatine analog cyclocreatine.

Publication ,  Journal Article
Martin, KJ; Vassallo, CD; Teicher, BA; Kaddurah-Daouk, R
Published in: Anticancer Drugs
June 1995

Creatine kinase (CK), a key enzyme of cellular energetics, has been implicated in tumorigenesis. Cyclocreatine (CCr), which forms a stable phosphagen with a reduced rate of ATP regeneration through CK, inhibits the growth of many solid tumors. We report that CCr induces the formation of unusually stable microtubules that resist depolymerization by nocodazole. By reducing ATP availability, CCr may modulate the activity of kinases that regulate microtubule dynamics. Further, combinations of CCr and taxol resulted in the synergistic killing of breast tumor cells indicating that CCr may be a useful addition to chemotherapy's that include taxanes.

Duke Scholars

Published In

Anticancer Drugs

DOI

ISSN

0959-4973

Publication Date

June 1995

Volume

6

Issue

3

Start / End Page

419 / 426

Location

England

Related Subject Headings

  • Uterine Cervical Neoplasms
  • Tumor Cells, Cultured
  • Paclitaxel
  • Oncology & Carcinogenesis
  • Nocodazole
  • Microtubules
  • Humans
  • Fluorescent Antibody Technique
  • Female
  • Drug Synergism
 

Citation

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MLA
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Martin, K. J., Vassallo, C. D., Teicher, B. A., & Kaddurah-Daouk, R. (1995). Microtubule stabilization and potentiation of taxol activity by the creatine analog cyclocreatine. Anticancer Drugs, 6(3), 419–426. https://doi.org/10.1097/00001813-199506000-00009
Martin, K. J., C. D. Vassallo, B. A. Teicher, and R. Kaddurah-Daouk. “Microtubule stabilization and potentiation of taxol activity by the creatine analog cyclocreatine.Anticancer Drugs 6, no. 3 (June 1995): 419–26. https://doi.org/10.1097/00001813-199506000-00009.
Martin KJ, Vassallo CD, Teicher BA, Kaddurah-Daouk R. Microtubule stabilization and potentiation of taxol activity by the creatine analog cyclocreatine. Anticancer Drugs. 1995 Jun;6(3):419–26.
Martin, K. J., et al. “Microtubule stabilization and potentiation of taxol activity by the creatine analog cyclocreatine.Anticancer Drugs, vol. 6, no. 3, June 1995, pp. 419–26. Pubmed, doi:10.1097/00001813-199506000-00009.
Martin KJ, Vassallo CD, Teicher BA, Kaddurah-Daouk R. Microtubule stabilization and potentiation of taxol activity by the creatine analog cyclocreatine. Anticancer Drugs. 1995 Jun;6(3):419–426.

Published In

Anticancer Drugs

DOI

ISSN

0959-4973

Publication Date

June 1995

Volume

6

Issue

3

Start / End Page

419 / 426

Location

England

Related Subject Headings

  • Uterine Cervical Neoplasms
  • Tumor Cells, Cultured
  • Paclitaxel
  • Oncology & Carcinogenesis
  • Nocodazole
  • Microtubules
  • Humans
  • Fluorescent Antibody Technique
  • Female
  • Drug Synergism