Inflammatory hypoxia: role of hypoxia-inducible factor.

Journal Article (Journal Article)

Sites of inflammation are characterized by significant changes in metabolic activity. Shifts in energy supply and demand can result in diminished delivery and/or availability of oxygen, leading to inflammation-associated tissue hypoxia and metabolic acidosis. These shifts in tissue metabolism, as indicated by previous studies, are frequently associated with vasculitis and profound recruitment of inflammatory cell types, particularly myeloid cells such as neutrophils (PMN) and monocytes. Here, we review recent work addressing the influence of hypoxia on development of inflammatory lesions, with particular emphasis on molecular pathways regulated by hypoxia-inducible factor (HIF).

Full Text

Duke Authors

Cited Authors

  • Karhausen, J; Haase, VH; Colgan, SP

Published Date

  • February 2005

Published In

Volume / Issue

  • 4 / 2

Start / End Page

  • 256 - 258

PubMed ID

  • 15655360

Electronic International Standard Serial Number (EISSN)

  • 1551-4005


  • eng

Conference Location

  • United States