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Reactive oxygen species in vascular endothelial cell motility. Roles of NAD(P)H oxidase and Rac1.

Publication ,  Journal Article
Moldovan, L; Mythreye, K; Goldschmidt-Clermont, PJ; Satterwhite, LL
Published in: Cardiovascular research
July 2006

Reactive oxygen species (ROS) are acknowledged generally to be multi-faceted regulators of cellular functions that trigger various pathological states when present chronically or transiently at non-physiologically high levels. Here we focus on the physiological involvement of ROS in cellular motility, with special emphasis on endothelial cells (EC). An important source of ROS within EC is the non-phagocytic NAD(P)H oxidase, and the small GTPase Rac1 plays a central role in activating this complex. Rac1 is one of the three Rho-family molecules (Rac, Rho and Cdc42) involved in the control of the actin cytoskeleton in response to various signals. In this review we examine the evidence linking ROS production, Rac1 activation and actin organization to EC motility, considering mechanisms for direct interaction of ROS and actin and the effects of ROS on proteins that regulate the actin cytoskeleton. The accumulated evidence suggests that ROS are important regulators of the actin cytoskeletal dynamics and cellular motility, and more in-depth studies are needed to understand the underlying mechanisms.

Duke Scholars

Published In

Cardiovascular research

DOI

EISSN

1755-3245

ISSN

0008-6363

Publication Date

July 2006

Volume

71

Issue

2

Start / End Page

236 / 246

Related Subject Headings

  • rac1 GTP-Binding Protein
  • Reactive Oxygen Species
  • Nitric Oxide
  • NADPH Oxidases
  • Humans
  • Enzyme Activation
  • Endothelial Cells
  • Cytoskeleton
  • Cell Movement
  • Cell Membrane
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Moldovan, L., Mythreye, K., Goldschmidt-Clermont, P. J., & Satterwhite, L. L. (2006). Reactive oxygen species in vascular endothelial cell motility. Roles of NAD(P)H oxidase and Rac1. Cardiovascular Research, 71(2), 236–246. https://doi.org/10.1016/j.cardiores.2006.05.003
Moldovan, Leni, Karthikeyan Mythreye, Pascal J. Goldschmidt-Clermont, and Lisa L. Satterwhite. “Reactive oxygen species in vascular endothelial cell motility. Roles of NAD(P)H oxidase and Rac1.Cardiovascular Research 71, no. 2 (July 2006): 236–46. https://doi.org/10.1016/j.cardiores.2006.05.003.
Moldovan L, Mythreye K, Goldschmidt-Clermont PJ, Satterwhite LL. Reactive oxygen species in vascular endothelial cell motility. Roles of NAD(P)H oxidase and Rac1. Cardiovascular research. 2006 Jul;71(2):236–46.
Moldovan, Leni, et al. “Reactive oxygen species in vascular endothelial cell motility. Roles of NAD(P)H oxidase and Rac1.Cardiovascular Research, vol. 71, no. 2, July 2006, pp. 236–46. Epmc, doi:10.1016/j.cardiores.2006.05.003.
Moldovan L, Mythreye K, Goldschmidt-Clermont PJ, Satterwhite LL. Reactive oxygen species in vascular endothelial cell motility. Roles of NAD(P)H oxidase and Rac1. Cardiovascular research. 2006 Jul;71(2):236–246.
Journal cover image

Published In

Cardiovascular research

DOI

EISSN

1755-3245

ISSN

0008-6363

Publication Date

July 2006

Volume

71

Issue

2

Start / End Page

236 / 246

Related Subject Headings

  • rac1 GTP-Binding Protein
  • Reactive Oxygen Species
  • Nitric Oxide
  • NADPH Oxidases
  • Humans
  • Enzyme Activation
  • Endothelial Cells
  • Cytoskeleton
  • Cell Movement
  • Cell Membrane