Atm deficiency affects both apoptosis and proliferation to augment Myc-induced lymphomagenesis.

Published

Journal Article

Myc oncoproteins are commonly activated in malignancies and are sufficient to provoke many types of cancer. However, the critical mechanisms by which Myc contributes to malignant transformation are not clear. DNA damage seems to be an important initiating event in tumorigenesis. Here, we show that although Myc does not directly induce double-stranded DNA breaks, it does augment activation of the Atm/p53 DNA damage response pathway, suggesting that Atm may function as a guardian against Myc-induced transformation. Indeed, we show that Atm loss augments Myc-induced lymphomagenesis and impairs Myc-induced apoptosis, which normally harnesses Myc-driven tumorigenesis. Surprisingly, Atm loss also augments the proliferative response induced by Myc, and this augmentation is associated with enhanced suppression of the expression of the cyclin-dependent kinase inhibitor p27(Kip1). Therefore, regulation of cell proliferation and p27(Kip1) seems to be a contributing mechanism by which Atm holds tumor formation in check.

Full Text

Duke Authors

Cited Authors

  • Maclean, KH; Kastan, MB; Cleveland, JL

Published Date

  • July 2007

Published In

Volume / Issue

  • 5 / 7

Start / End Page

  • 705 - 711

PubMed ID

  • 17634425

Pubmed Central ID

  • 17634425

International Standard Serial Number (ISSN)

  • 1541-7786

Digital Object Identifier (DOI)

  • 10.1158/1541-7786.MCR-07-0058

Language

  • eng

Conference Location

  • United States