ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome.

Journal Article (Journal Article)

Metabolic syndrome is associated with insulin resistance and atherosclerosis. Here, we show that deficiency of one or two alleles of ATM, the protein mutated in the cancer-prone disease ataxia telangiectasia, worsens features of the metabolic syndrome, increases insulin resistance, and accelerates atherosclerosis in apoE-/- mice. Transplantation with ATM-/- as compared to ATM+/+ bone marrow increased vascular disease. Jun N-terminal kinase (JNK) activity was increased in ATM-deficient cells. Treatment of ATM+/+apoE-/- mice with low-dose chloroquine, an ATM activator, decreased atherosclerosis. In an ATM-dependent manner, chloroquine decreased macrophage JNK activity, decreased macrophage lipoprotein lipase activity (a proatherogenic consequence of JNK activation), decreased blood pressure, and improved glucose tolerance. Chloroquine also improved metabolic abnormalities in ob/ob and db/db mice. These results suggest that ATM-dependent stress pathways mediate susceptibility to the metabolic syndrome and that chloroquine or related agents promoting ATM activity could modulate insulin resistance and decrease vascular disease.

Full Text

Duke Authors

Cited Authors

  • Schneider, JG; Finck, BN; Ren, J; Standley, KN; Takagi, M; Maclean, KH; Bernal-Mizrachi, C; Muslin, AJ; Kastan, MB; Semenkovich, CF

Published Date

  • November 2006

Published In

Volume / Issue

  • 4 / 5

Start / End Page

  • 377 - 389

PubMed ID

  • 17084711

International Standard Serial Number (ISSN)

  • 1550-4131

Digital Object Identifier (DOI)

  • 10.1016/j.cmet.2006.10.002


  • eng

Conference Location

  • United States