Cell-cycle checkpoints and cancer.


Journal Article (Review)

All life on earth must cope with constant exposure to DNA-damaging agents such as the Sun's radiation. Highly conserved DNA-repair and cell-cycle checkpoint pathways allow cells to deal with both endogenous and exogenous sources of DNA damage. How much an individual is exposed to these agents and how their cells respond to DNA damage are critical determinants of whether that individual will develop cancer. These cellular responses are also important for determining toxicities and responses to current cancer therapies, most of which target the DNA.

Full Text

Duke Authors

Cited Authors

  • Kastan, MB; Bartek, J

Published Date

  • November 18, 2004

Published In

Volume / Issue

  • 432 / 7015

Start / End Page

  • 316 - 323

PubMed ID

  • 15549093

Pubmed Central ID

  • 15549093

Electronic International Standard Serial Number (EISSN)

  • 1476-4687

Digital Object Identifier (DOI)

  • 10.1038/nature03097


  • eng

Conference Location

  • England