Initiating cellular stress responses.

Journal Article (Journal Article;Review)

The phosphoinositide 3-kinase related kinases (PIKKs) mediate responses to diverse stresses, including DNA double-strand breaks (DSBs), abnormal replication fork progression, the recognition of premature termination codons in mRNAs, and inadequate nutrient availability. Rigorous control of these kinases limits cellular damage and promotes cell viability in the presence of stress. Control mechanisms include the localization of PIKKs into multiprotein complexes at the sites of damage and mediation of protein-protein contacts such that substrates are allowed access to the PIKK catalytic domains.

Full Text

Duke Authors

Cited Authors

  • Bakkenist, CJ; Kastan, MB

Published Date

  • July 9, 2004

Published In

Volume / Issue

  • 118 / 1

Start / End Page

  • 9 - 17

PubMed ID

  • 15242640

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2004.06.023


  • eng

Conference Location

  • United States