Phosphatases join kinases in DNA-damage response pathways.

Journal Article (Journal Article;Review)

An inappropriate imbalance of kinase and phosphatase activities could be deleterious to cellular processes such as proliferation. Cellular responses to DNA damage use signal-transduction pathways involving phosphorylation events, and such modifications must be reversible to make these responses transient, rather than permanent, events. Three recent articles describe roles for two phosphatases in signaling pathways that are activated after DNA damage.

Full Text

Duke Authors

Cited Authors

  • Bakkenist, CJ; Kastan, MB

Published Date

  • July 1, 2004

Published In

Volume / Issue

  • 14 / 7

Start / End Page

  • 339 - 341

PubMed ID

  • 15246426

International Standard Serial Number (ISSN)

  • 0962-8924

Digital Object Identifier (DOI)

  • 10.1016/j.tcb.2004.05.001


  • eng

Conference Location

  • England