Phosphatases join kinases in DNA-damage response pathways.
Journal Article (Journal Article;Review)
An inappropriate imbalance of kinase and phosphatase activities could be deleterious to cellular processes such as proliferation. Cellular responses to DNA damage use signal-transduction pathways involving phosphorylation events, and such modifications must be reversible to make these responses transient, rather than permanent, events. Three recent articles describe roles for two phosphatases in signaling pathways that are activated after DNA damage.
Full Text
Duke Authors
Cited Authors
- Bakkenist, CJ; Kastan, MB
Published Date
- July 1, 2004
Published In
Volume / Issue
- 14 / 7
Start / End Page
- 339 - 341
PubMed ID
- 15246426
International Standard Serial Number (ISSN)
- 0962-8924
Digital Object Identifier (DOI)
- 10.1016/j.tcb.2004.05.001
Language
- eng
Conference Location
- England