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Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.

Publication ,  Journal Article
Smith, ML; Chen, IT; Zhan, Q; Bae, I; Chen, CY; Gilmer, TM; Kastan, MB; O'Connor, PM; Fornace, AJ
Published in: Science
November 25, 1994

GADD45 is a ubiquitously expressed mammalian gene that is induced by DNA damage and certain other stresses. Like another p53-regulated gene, p21WAF1/CIP1, whose product binds to cyclin-dependent kinases (Cdk's) and proliferating cell nuclear antigen (PCNA), GADD45 has been associated with growth suppression. Gadd45 was found to bind to PCNA, a normal component of Cdk complexes and a protein involved in DNA replication and repair. Gadd45 stimulated DNA excision repair in vitro and inhibited entry of cells into S phase. These results establish GADD45 as a link between the p53-dependent cell cycle checkpoint and DNA repair.

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Published In

Science

DOI

ISSN

0036-8075

Publication Date

November 25, 1994

Volume

266

Issue

5189

Start / End Page

1376 / 1380

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Transfection
  • S Phase
  • Recombinant Proteins
  • Proteins
  • Proliferating Cell Nuclear Antigen
  • Intracellular Signaling Peptides and Proteins
  • Humans
  • Genes, p53
  • General Science & Technology
 

Citation

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Smith, M. L., Chen, I. T., Zhan, Q., Bae, I., Chen, C. Y., Gilmer, T. M., … Fornace, A. J. (1994). Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science, 266(5189), 1376–1380. https://doi.org/10.1126/science.7973727
Smith, M. L., I. T. Chen, Q. Zhan, I. Bae, C. Y. Chen, T. M. Gilmer, M. B. Kastan, P. M. O’Connor, and A. J. Fornace. “Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.Science 266, no. 5189 (November 25, 1994): 1376–80. https://doi.org/10.1126/science.7973727.
Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, et al. Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science. 1994 Nov 25;266(5189):1376–80.
Smith, M. L., et al. “Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.Science, vol. 266, no. 5189, Nov. 1994, pp. 1376–80. Pubmed, doi:10.1126/science.7973727.
Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O’Connor PM, Fornace AJ. Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science. 1994 Nov 25;266(5189):1376–1380.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

November 25, 1994

Volume

266

Issue

5189

Start / End Page

1376 / 1380

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Transfection
  • S Phase
  • Recombinant Proteins
  • Proteins
  • Proliferating Cell Nuclear Antigen
  • Intracellular Signaling Peptides and Proteins
  • Humans
  • Genes, p53
  • General Science & Technology