Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.

Journal Article (Journal Article)

GADD45 is a ubiquitously expressed mammalian gene that is induced by DNA damage and certain other stresses. Like another p53-regulated gene, p21WAF1/CIP1, whose product binds to cyclin-dependent kinases (Cdk's) and proliferating cell nuclear antigen (PCNA), GADD45 has been associated with growth suppression. Gadd45 was found to bind to PCNA, a normal component of Cdk complexes and a protein involved in DNA replication and repair. Gadd45 stimulated DNA excision repair in vitro and inhibited entry of cells into S phase. These results establish GADD45 as a link between the p53-dependent cell cycle checkpoint and DNA repair.

Full Text

Duke Authors

Cited Authors

  • Smith, ML; Chen, IT; Zhan, Q; Bae, I; Chen, CY; Gilmer, TM; Kastan, MB; O'Connor, PM; Fornace, AJ

Published Date

  • November 25, 1994

Published In

Volume / Issue

  • 266 / 5189

Start / End Page

  • 1376 - 1380

PubMed ID

  • 7973727

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.7973727


  • eng

Conference Location

  • United States