Cell cycle control and cancer.
Journal Article (Journal Article;Review)
Multiple genetic changes occur during the evolution of normal cells into cancer cells. This evolution is facilitated in cancer cells by loss of fidelity in the processes that replicate, repair, and segregate the genome. Recent advances in our understanding of the cell cycle reveal how fidelity is normally achieved by the coordinated activity of cyclin-dependent kinases, checkpoint controls, and repair pathways and how this fidelity can be abrogated by specific genetic changes. These insights suggest molecular mechanisms for cellular transformation and may help to identify potential targets for improved cancer therapies.
Full Text
Duke Authors
Cited Authors
- Hartwell, LH; Kastan, MB
Published Date
- December 16, 1994
Published In
Volume / Issue
- 266 / 5192
Start / End Page
- 1821 - 1828
PubMed ID
- 7997877
International Standard Serial Number (ISSN)
- 0036-8075
Digital Object Identifier (DOI)
- 10.1126/science.7997877
Language
- eng
Conference Location
- United States