DISC1-dependent switch from progenitor proliferation to migration in the developing cortex.


Journal Article

Regulatory mechanisms governing the sequence from progenitor cell proliferation to neuronal migration during corticogenesis are poorly understood. Here we report that phosphorylation of DISC1, a major susceptibility factor for several mental disorders, acts as a molecular switch from maintaining proliferation of mitotic progenitor cells to activating migration of postmitotic neurons in mice. Unphosphorylated DISC1 regulates canonical Wnt signalling via an interaction with GSK3β, whereas specific phosphorylation at serine 710 (S710) triggers the recruitment of Bardet-Biedl syndrome (BBS) proteins to the centrosome. In support of this model, loss of BBS1 leads to defects in migration, but not proliferation, whereas DISC1 knockdown leads to deficits in both. A phospho-dead mutant can only rescue proliferation, whereas a phospho-mimic mutant rescues exclusively migration defects. These data highlight a dual role for DISC1 in corticogenesis and indicate that phosphorylation of this protein at S710 activates a key developmental switch.

Full Text

Cited Authors

  • Ishizuka, K; Kamiya, A; Oh, EC; Kanki, H; Seshadri, S; Robinson, JF; Murdoch, H; Dunlop, AJ; Kubo, K-I; Furukori, K; Huang, B; Zeledon, M; Hayashi-Takagi, A; Okano, H; Nakajima, K; Houslay, MD; Katsanis, N; Sawa, A

Published Date

  • May 5, 2011

Published In

Volume / Issue

  • 473 / 7345

Start / End Page

  • 92 - 96

PubMed ID

  • 21471969

Pubmed Central ID

  • 21471969

Electronic International Standard Serial Number (EISSN)

  • 1476-4687

Digital Object Identifier (DOI)

  • 10.1038/nature09859


  • eng

Conference Location

  • England