Planar cell polarity acts through septins to control collective cell movement and ciliogenesis.

Published

Journal Article

The planar cell polarity (PCP) signaling pathway governs collective cell movements during vertebrate embryogenesis, and certain PCP proteins are also implicated in the assembly of cilia. The septins are cytoskeletal proteins controlling behaviors such as cell division and migration. Here, we identified control of septin localization by the PCP protein Fritz as a crucial control point for both collective cell movement and ciliogenesis in Xenopus embryos. We also linked mutations in human Fritz to Bardet-Biedl and Meckel-Gruber syndromes, a notable link given that other genes mutated in these syndromes also influence collective cell movement and ciliogenesis. These findings shed light on the mechanisms by which fundamental cellular machinery, such as the cytoskeleton, is regulated during embryonic development and human disease.

Full Text

Duke Authors

Cited Authors

  • Kim, SK; Shindo, A; Park, TJ; Oh, EC; Ghosh, S; Gray, RS; Lewis, RA; Johnson, CA; Attie-Bittach, T; Katsanis, N; Wallingford, JB

Published Date

  • September 2010

Published In

Volume / Issue

  • 329 / 5997

Start / End Page

  • 1337 - 1340

PubMed ID

  • 20671153

Pubmed Central ID

  • 20671153

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1191184

Language

  • eng