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Standardizing the use of the Continuous Performance Test in schizophrenia research: a validation study.

Publication ,  Journal Article
Kahn, PV; Walker, TM; Williams, TS; Cornblatt, BA; Mohs, RC; Keefe, RSE
Published in: Schizophr Res
December 2012

BACKGROUND: The Continuous Performance Test (CPT) has emerged as the most commonly administered measure of sustained attention, but use of discrepant versions reduces the ability of researchers and clinicians to accurately draw cross-study conclusions. In an effort to standardize use of the CPT, this study compared four versions of the Identical Pairs CPT for their reliability and ability to discriminate between patients with schizophrenia and healthy volunteers. The relationship of performance on the different versions of the CPT with measures of psychopathology, functioning, and other aspects of cognition was also examined. METHODS: Performance on the 2-digit, 3-digit, 4-digit, and Shapes Identical Pairs CPT was assessed at three test sessions over five weeks, during which subjects also completed the Brief Assessment of Cognition in Schizophrenia (BACS) and questionnaires assessing psychopathology and functioning. RESULTS: All four CPTs discriminated between patients with schizophrenia and healthy volunteers, but there were no statistical differences in sensitivity among the versions. The 3-digit CPT showed non-statistical advantages in that it had high test-retest reliability, low potential for a ceiling effect, and a very low rate of false alarms. There were also moderate correlations between CPT performance and performance of the BACS subtests, but no significant correlations between CPT performance and measures of psychopathology and functioning. CONCLUSIONS: While all versions of the CPT tested here had good psychometric characteristics, the 3-digit CPT-IP has some advantages in repeated measures studies such as clinical trials.

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Published In

Schizophr Res

DOI

EISSN

1573-2509

Publication Date

December 2012

Volume

142

Issue

1-3

Start / End Page

153 / 158

Location

Netherlands

Related Subject Headings

  • Young Adult
  • Sensitivity and Specificity
  • Schizophrenic Psychology
  • Schizophrenia
  • Reproducibility of Results
  • Reference Values
  • Psychiatry
  • Neuropsychological Tests
  • Male
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Kahn, P. V., Walker, T. M., Williams, T. S., Cornblatt, B. A., Mohs, R. C., & Keefe, R. S. E. (2012). Standardizing the use of the Continuous Performance Test in schizophrenia research: a validation study. Schizophr Res, 142(1–3), 153–158. https://doi.org/10.1016/j.schres.2012.09.009
Kahn, Phoebe V., Trina M. Walker, Teresa S. Williams, Barbara A. Cornblatt, Richard C. Mohs, and Richard S. E. Keefe. “Standardizing the use of the Continuous Performance Test in schizophrenia research: a validation study.Schizophr Res 142, no. 1–3 (December 2012): 153–58. https://doi.org/10.1016/j.schres.2012.09.009.
Kahn PV, Walker TM, Williams TS, Cornblatt BA, Mohs RC, Keefe RSE. Standardizing the use of the Continuous Performance Test in schizophrenia research: a validation study. Schizophr Res. 2012 Dec;142(1–3):153–8.
Kahn, Phoebe V., et al. “Standardizing the use of the Continuous Performance Test in schizophrenia research: a validation study.Schizophr Res, vol. 142, no. 1–3, Dec. 2012, pp. 153–58. Pubmed, doi:10.1016/j.schres.2012.09.009.
Kahn PV, Walker TM, Williams TS, Cornblatt BA, Mohs RC, Keefe RSE. Standardizing the use of the Continuous Performance Test in schizophrenia research: a validation study. Schizophr Res. 2012 Dec;142(1–3):153–158.
Journal cover image

Published In

Schizophr Res

DOI

EISSN

1573-2509

Publication Date

December 2012

Volume

142

Issue

1-3

Start / End Page

153 / 158

Location

Netherlands

Related Subject Headings

  • Young Adult
  • Sensitivity and Specificity
  • Schizophrenic Psychology
  • Schizophrenia
  • Reproducibility of Results
  • Reference Values
  • Psychiatry
  • Neuropsychological Tests
  • Male
  • Humans