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Integrated genetic and genomic approach in the SingaporeTranslational and Clinical Research in Psychosis Study: an overview.

Publication ,  Journal Article
Sim, K; Lee, J; Subramaniam, M; Liu, JJ; Keefe, R; Zhang, XD; Lee, TS; Chong, SA
Published in: Early Interv Psychiatry
May 2011

AIMS: Schizophrenia is a severe mental disorder with onset frequently in adolescence and followed by a chronic and disabling course. Although the exact pathophysiology of this devastating disorder has not been clearly elucidated, a large part of it has been attributed to genetic influences. This article seeks to provide an overview on what our group has embarked on--to elucidate genetic risk factors for schizophrenia within the Chinese ethnic group. METHODS: We plan to conduct an integrated approach to interrogate comprehensively the genome from different angles and in stages. The first stage involves a genome-wide association study of 1000 cases of schizophrenia-control pairs, with a follow-up replication study in another 1000 cases of schizophrenia and in 1000 controls, and combination analyses with groups from other places including China and Hong Kong. Other than the genome-wide association study, gene sequencing for purported candidate genes and copy number variation analysis will be performed. Neurocognitive intermediate phenotypes will be employed to deconstruct the complex schizophrenia phenotype in a bid to improve association findings. Promising leads from longitudinal gene and protein expression in ultra-high-risk subjects who develop psychosis and schizophrenia (in a parallel study) will be followed up as candidate genes and sequenced in the genetic analysis. Functional analysis forms the last stage of this integrated approach. CONCLUSION: This integrated genetic and genomic approach will hopefully help in further characterizing and deepening our understanding of molecular pathophysiological mechanisms underlying schizophrenia.

Duke Scholars

Published In

Early Interv Psychiatry

DOI

EISSN

1751-7893

Publication Date

May 2011

Volume

5

Issue

2

Start / End Page

91 / 99

Location

Australia

Related Subject Headings

  • Translational Research, Biomedical
  • Singapore
  • Schizophrenic Psychology
  • Schizophrenia
  • Research Design
  • Psychiatry
  • Humans
  • Genome-Wide Association Study
  • Genome, Human
  • Genetic Predisposition to Disease
 

Citation

APA
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ICMJE
MLA
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Sim, K., Lee, J., Subramaniam, M., Liu, J. J., Keefe, R., Zhang, X. D., … Chong, S. A. (2011). Integrated genetic and genomic approach in the SingaporeTranslational and Clinical Research in Psychosis Study: an overview. Early Interv Psychiatry, 5(2), 91–99. https://doi.org/10.1111/j.1751-7893.2011.00272.x
Sim, Kang, Jimmy Lee, Mythily Subramaniam, Jian Jun Liu, Richard Keefe, Xiao Dong Zhang, Tih Shih Lee, and Siow Ann Chong. “Integrated genetic and genomic approach in the SingaporeTranslational and Clinical Research in Psychosis Study: an overview.Early Interv Psychiatry 5, no. 2 (May 2011): 91–99. https://doi.org/10.1111/j.1751-7893.2011.00272.x.
Sim K, Lee J, Subramaniam M, Liu JJ, Keefe R, Zhang XD, et al. Integrated genetic and genomic approach in the SingaporeTranslational and Clinical Research in Psychosis Study: an overview. Early Interv Psychiatry. 2011 May;5(2):91–9.
Sim, Kang, et al. “Integrated genetic and genomic approach in the SingaporeTranslational and Clinical Research in Psychosis Study: an overview.Early Interv Psychiatry, vol. 5, no. 2, May 2011, pp. 91–99. Pubmed, doi:10.1111/j.1751-7893.2011.00272.x.
Sim K, Lee J, Subramaniam M, Liu JJ, Keefe R, Zhang XD, Lee TS, Chong SA. Integrated genetic and genomic approach in the SingaporeTranslational and Clinical Research in Psychosis Study: an overview. Early Interv Psychiatry. 2011 May;5(2):91–99.
Journal cover image

Published In

Early Interv Psychiatry

DOI

EISSN

1751-7893

Publication Date

May 2011

Volume

5

Issue

2

Start / End Page

91 / 99

Location

Australia

Related Subject Headings

  • Translational Research, Biomedical
  • Singapore
  • Schizophrenic Psychology
  • Schizophrenia
  • Research Design
  • Psychiatry
  • Humans
  • Genome-Wide Association Study
  • Genome, Human
  • Genetic Predisposition to Disease