No association of the serotonin transporter polymorphisms 5-HTTLPR and RS25531 with schizophrenia or neurocognition.

Journal Article (Journal Article)

A promoter polymorphism in the serotonin transporter gene has been widely studied in neuropsychiatry. We genotyped the 5-HTTLPR/rs25531 triallelic polymorphism in 728 schizophrenia cases from the CATIE study and 724 control subjects. In a logistic regression with case/control status as dependent variable and 7 ancestry-informative principal components as covariates, the effect of 5-HTTLPR/rs25531 composite genotype was not significant (odds ratio = 1.008, 95% CI 0.868-1.172, P = 0.91). In cases only, 5-HTTLPR/rs25531 was not associated with neurocognition (summary neurocognitive index P = 0.21, working memory P = 0.32) or symptomatology (PANSS positive P = 0.67 and negative symptoms P = 0.46). We were unable to identify association of the triallelic 5-HTTLPR with schizophrenia, neurocognition, or core psychotic symptoms even at levels of significance unadjusted for multiple comparisons.

Full Text

Duke Authors

Cited Authors

  • Konneker, TI; Crowley, JJ; Quackenbush, CR; Keefe, RSE; Perkins, DO; Stroup, TS; Lieberman, JA; van den Oord, E; Sullivan, PF

Published Date

  • July 2010

Published In

Volume / Issue

  • 153B / 5

Start / End Page

  • 1115 - 1117

PubMed ID

  • 20468059

Pubmed Central ID

  • PMC3181051

Electronic International Standard Serial Number (EISSN)

  • 1552-485X

Digital Object Identifier (DOI)

  • 10.1002/ajmg.b.31077


  • eng

Conference Location

  • United States