Memory-prediction errors and their consequences in schizophrenia.

Journal Article (Journal Article;Review)

Cognitive deficits play a central role in the onset of schizophrenia. Cognitive impairment precedes the onset of psychosis in at least a subgroup of patients, and accounts for considerable dysfunction. Yet cognitive deficits as currently measured are not significantly related to hallucinations and delusions. Part of this counterintuitive absence of a relationship may be caused by the lack of an organizing principle of cognitive impairment in schizophrenia research. We review literature suggesting that a system of memory-based prediction is central to human perception, thought and action , and forward the notion that many of the symptoms of schizophrenia are a result of a failure of this system.

Full Text

Duke Authors

Cited Authors

  • Kraus, MS; Keefe, RSE; Krishnan, RKR

Published Date

  • September 2009

Published In

Volume / Issue

  • 19 / 3

Start / End Page

  • 336 - 352

PubMed ID

  • 19575296

Electronic International Standard Serial Number (EISSN)

  • 1573-6660

Digital Object Identifier (DOI)

  • 10.1007/s11065-009-9106-1


  • eng

Conference Location

  • United States