Neuropsychological course in the prodrome and first episode of psychosis: findings from the PRIME North America Double Blind Treatment Study.

Published

Journal Article

There is uncertainty regarding the onset timing of the cognitive deficiencies of schizophrenia. We investigated whether conversion to psychosis and/or olanzapine altered the neuropsychological course of subjects within the first-ever double blind medication study of the putative schizophrenia first episode prodrome.Sixty participants in a double blind trial of olanzapine as a treatment for putative prodromal states were assessed at entry (pre-randomization), and again at 6 and 12 months (if they remained non-psychotic), or at any of these points prior to psychosis followed by post-psychosis and 6 months post-psychosis assessments.Participants who converted to psychosis did not differ from placebo non-converters in pre-randomization global neuropsychological status. Early converters did not differ from later converters in entry neuropsychological status. Subjects who converted after 6 months did not show neuropsychological declines during the initial, pre-psychosis, 6 months. Neuropsychological course did not differ between converters to psychosis and non-converters, or between olanzapine and placebo-assigned subjects.Neither the onset of frank psychosis nor olanzapine treatment of the prodrome significantly alters neuropsychological course in persons considered to be at high risk at their initial (pre-psychosis) assessment. These findings suggest that the neuropsychological deficiencies associated with psychotic conditions largely pre-exist the first frank psychotic episode.

Full Text

Duke Authors

Cited Authors

  • Hawkins, KA; Keefe, RSE; Christensen, BK; Addington, J; Woods, SW; Callahan, J; Zipursky, RB; Perkins, DO; Tohen, M; Breier, A; McGlashan, TH

Published Date

  • October 2008

Published In

Volume / Issue

  • 105 / 1-3

Start / End Page

  • 1 - 9

PubMed ID

  • 18774696

Pubmed Central ID

  • 18774696

Electronic International Standard Serial Number (EISSN)

  • 1573-2509

International Standard Serial Number (ISSN)

  • 0920-9964

Digital Object Identifier (DOI)

  • 10.1016/j.schres.2008.07.008

Language

  • eng