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Defining a cognitive function decrement in schizophrenia.

Publication ,  Journal Article
Keefe, RSE; Eesley, CE; Poe, MP
Published in: Biol Psychiatry
March 15, 2005

BACKGROUND: Although cognitive impairment is described as a core component of the characterization of schizophrenia, a sizable percentage of patients are classified as unimpaired by traditional definitions of impairment. The purpose of this study was to determine the percentage of patients with schizophrenia meeting criteria for a "cognitive function decrement" defined as a current level of cognitive function that falls below the level predicted by premorbid estimates. METHODS: Linear regression analyses were performed on a healthy control population to determine a predicted composite cognitive score based on maternal education, paternal education, and reading score as indicators of premorbid intellectual function. The percentages of patients with current cognitive function above and below predicted values were calculated. RESULTS: When the Wide Range Achievement Test-3 (WRAT-3) score and maternal education are both used to predict current cognitive performance, as expected, about half (42%) of control subjects fall below expectations. However, 98.1 % of patients fall below expectations. CONCLUSIONS: When cognitive function decrement is defined as a failure to reach the expected level of cognitive functioning, almost all patients with schizophrenia meet this definition.

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Published In

Biol Psychiatry

DOI

ISSN

0006-3223

Publication Date

March 15, 2005

Volume

57

Issue

6

Start / End Page

688 / 691

Location

United States

Related Subject Headings

  • Schizophrenic Psychology
  • Schizophrenia
  • Regression Analysis
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Neuropsychological Tests
  • Intelligence Tests
  • Intelligence
  • Humans
  • Confidence Intervals
 

Citation

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Keefe, R. S. E., Eesley, C. E., & Poe, M. P. (2005). Defining a cognitive function decrement in schizophrenia. Biol Psychiatry, 57(6), 688–691. https://doi.org/10.1016/j.biopsych.2005.01.003
Keefe, Richard S. E., Charles E. Eesley, and Margaret P. Poe. “Defining a cognitive function decrement in schizophrenia.Biol Psychiatry 57, no. 6 (March 15, 2005): 688–91. https://doi.org/10.1016/j.biopsych.2005.01.003.
Keefe RSE, Eesley CE, Poe MP. Defining a cognitive function decrement in schizophrenia. Biol Psychiatry. 2005 Mar 15;57(6):688–91.
Keefe, Richard S. E., et al. “Defining a cognitive function decrement in schizophrenia.Biol Psychiatry, vol. 57, no. 6, Mar. 2005, pp. 688–91. Pubmed, doi:10.1016/j.biopsych.2005.01.003.
Keefe RSE, Eesley CE, Poe MP. Defining a cognitive function decrement in schizophrenia. Biol Psychiatry. 2005 Mar 15;57(6):688–691.
Journal cover image

Published In

Biol Psychiatry

DOI

ISSN

0006-3223

Publication Date

March 15, 2005

Volume

57

Issue

6

Start / End Page

688 / 691

Location

United States

Related Subject Headings

  • Schizophrenic Psychology
  • Schizophrenia
  • Regression Analysis
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Neuropsychological Tests
  • Intelligence Tests
  • Intelligence
  • Humans
  • Confidence Intervals