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Eye tracking, attention, and schizotypal symptoms in nonpsychotic relatives of patients with schizophrenia.

Publication ,  Journal Article
Keefe, RS; Silverman, JM; Mohs, RC; Siever, LJ; Harvey, PD; Friedman, L; Roitman, SE; DuPre, RL; Smith, CJ; Schmeidler, J; Davis, KL
Published in: Arch Gen Psychiatry
February 1997

BACKGROUND: Biological relatives of patients with schizophrenia demonstrate an increased prevalence of schizotypal personality disorder symptoms, eye tracking deficits, and attentional disturbances. We investigated whether these hypothesized components of a schizophrenia-related phenotype are associated with one another or are independent in nonpsychotic relatives of patients with schizophrenia. METHODS: Eighty-three nonpsychotic first-degree relatives of 38 patients with schizophrenia and 45 control subjects without a psychiatric diagnosis underwent clinical evaluation, eye tracking evaluation, and the Continuous Performance Test (CPT) of visual attention. RESULTS: Eye tracking qualitative rating was more powerful than quantitative eye tracking measures or CPT measures in discriminating relatives of patients with schizophrenia from control subjects. Correlations between neurocognitive variables and DSM-III-R schizotypal personality disorder symptom clusters suggested that CPT errors of omission are associated with positive schizotypal symptoms. Eye tracking measures were not significantly correlated with schizotypal symptoms or CPT errors in relatives of patients with schizophrenia. CONCLUSIONS: Eye tracking deficits in the relatives of patients with schizophrenia are unrelated to CPT deficits and schizotypal symptoms. Eye tracking deficits and disturbances in visual attention may be separate components of a schizophrenia-related phenotype and should be considered as independent factors in genetic studies of schizophrenia.

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Published In

Arch Gen Psychiatry

DOI

ISSN

0003-990X

Publication Date

February 1997

Volume

54

Issue

2

Start / End Page

169 / 176

Location

United States

Related Subject Headings

  • Wechsler Scales
  • Visual Perception
  • Schizotypal Personality Disorder
  • Schizophrenic Psychology
  • Schizophrenia
  • Saccades
  • Psychomotor Performance
  • Psychological Tests
  • Psychiatry
  • Neuropsychological Tests
 

Citation

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Keefe, R. S., Silverman, J. M., Mohs, R. C., Siever, L. J., Harvey, P. D., Friedman, L., … Davis, K. L. (1997). Eye tracking, attention, and schizotypal symptoms in nonpsychotic relatives of patients with schizophrenia. Arch Gen Psychiatry, 54(2), 169–176. https://doi.org/10.1001/archpsyc.1997.01830140081014
Keefe, R. S., J. M. Silverman, R. C. Mohs, L. J. Siever, P. D. Harvey, L. Friedman, S. E. Roitman, et al. “Eye tracking, attention, and schizotypal symptoms in nonpsychotic relatives of patients with schizophrenia.Arch Gen Psychiatry 54, no. 2 (February 1997): 169–76. https://doi.org/10.1001/archpsyc.1997.01830140081014.
Keefe RS, Silverman JM, Mohs RC, Siever LJ, Harvey PD, Friedman L, et al. Eye tracking, attention, and schizotypal symptoms in nonpsychotic relatives of patients with schizophrenia. Arch Gen Psychiatry. 1997 Feb;54(2):169–76.
Keefe, R. S., et al. “Eye tracking, attention, and schizotypal symptoms in nonpsychotic relatives of patients with schizophrenia.Arch Gen Psychiatry, vol. 54, no. 2, Feb. 1997, pp. 169–76. Pubmed, doi:10.1001/archpsyc.1997.01830140081014.
Keefe RS, Silverman JM, Mohs RC, Siever LJ, Harvey PD, Friedman L, Roitman SE, DuPre RL, Smith CJ, Schmeidler J, Davis KL. Eye tracking, attention, and schizotypal symptoms in nonpsychotic relatives of patients with schizophrenia. Arch Gen Psychiatry. 1997 Feb;54(2):169–176.

Published In

Arch Gen Psychiatry

DOI

ISSN

0003-990X

Publication Date

February 1997

Volume

54

Issue

2

Start / End Page

169 / 176

Location

United States

Related Subject Headings

  • Wechsler Scales
  • Visual Perception
  • Schizotypal Personality Disorder
  • Schizophrenic Psychology
  • Schizophrenia
  • Saccades
  • Psychomotor Performance
  • Psychological Tests
  • Psychiatry
  • Neuropsychological Tests