D-amphetamine challenge effects on Wisconsin Card Sort Test. Performance in schizotypal personality disorder.

Journal Article (Clinical Trial;Journal Article)

The authors assessed the effects on Wisconsin Card Sort (WCST) performance and psychiatric symptoms of 30 mg d-amphetamine, a dopamine and norepinephrine agonist, vs placebo in nine patients with schizotypal personality disorder (SPD). Patients, particularly those who made more perseverative errors, demonstrated amphetamine-associated improvement on WCST performance. The data in this preliminary study suggest that some of the cognitive dysfunction present in SPD may improve with amphetamine challenge.

Full Text

Duke Authors

Cited Authors

  • Siegel, BV; Trestman, RL; O'Flaithbheartaigh, S; Mitropoulou, V; Amin, F; Kirrane, R; Silverman, J; Schmeidler, J; Keefe, RS; Siever, LJ

Published Date

  • May 1996

Published In

Volume / Issue

  • 20 / 1-2

Start / End Page

  • 29 - 32

PubMed ID

  • 8794491

International Standard Serial Number (ISSN)

  • 0920-9964

Digital Object Identifier (DOI)

  • 10.1016/0920-9964(95)00002-x


  • eng

Conference Location

  • Netherlands