D-amphetamine challenge effects on Wisconsin Card Sort Test. Performance in schizotypal personality disorder.
Journal Article (Clinical Trial;Journal Article)
The authors assessed the effects on Wisconsin Card Sort (WCST) performance and psychiatric symptoms of 30 mg d-amphetamine, a dopamine and norepinephrine agonist, vs placebo in nine patients with schizotypal personality disorder (SPD). Patients, particularly those who made more perseverative errors, demonstrated amphetamine-associated improvement on WCST performance. The data in this preliminary study suggest that some of the cognitive dysfunction present in SPD may improve with amphetamine challenge.
- Siegel, BV; Trestman, RL; O'Flaithbheartaigh, S; Mitropoulou, V; Amin, F; Kirrane, R; Silverman, J; Schmeidler, J; Keefe, RS; Siever, LJ
- May 1996
Volume / Issue
- 20 / 1-2
Start / End Page
- 29 - 32
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)