Safety of urate-lowering therapies: managing the risks to gain the benefits.


Journal Article (Review)

Gout is a metabolic disorder of purine metabolism and uric acid elimination. Over time, acute gout can develop into a chronic, disabling arthropathy, often associated with multiple comorbidities. Gout patients have often been undertreated, partly because of the clinician's perceived risks of a therapy outweighing its potential benefits. The approval of new therapies to treat hyperuricemia in gout has led to a new understanding of gout management and medication safety regarding new and old therapies. This review focuses on potential safety issues of currently available urate-lowering therapies and outlines strategies to minimize risks so their benefits can be reached.

Full Text

Duke Authors

Cited Authors

  • Keenan, RT

Published Date

  • November 2012

Published In

Volume / Issue

  • 38 / 4

Start / End Page

  • 663 - 680

PubMed ID

  • 23137576

Pubmed Central ID

  • 23137576

Electronic International Standard Serial Number (EISSN)

  • 1558-3163

Digital Object Identifier (DOI)

  • 10.1016/j.rdc.2012.08.008


  • eng

Conference Location

  • United States