Eukaryotic mRNPs may represent posttranscriptional operons.

Journal Article

Genomic array analysis of endogenous mammalian ribonucleoproteins has recently revealed three novel findings: (1) mRNA binding proteins are associated with unique subpopulations of messages, (2) the compositions of these mRNA subsets can vary with growth conditions, and (3) the same mRNA species can be found in multiple mRNP complexes. Based on these and other findings, we propose a model of posttranscriptional gene expression in which mRNA binding proteins regulate mRNAs as subpopulations during cell growth and development. This model predicts that functionally related genes are regulated posttranscriptionally as groups by specific mRNA binding proteins that recognize sequence elements in common among the mRNAs.

Full Text

Duke Authors

Cited Authors

  • Keene, JD; Tenenbaum, SA

Published Date

  • June 2002

Published In

Volume / Issue

  • 9 / 6

Start / End Page

  • 1161 - 1167

PubMed ID

  • 12086614

International Standard Serial Number (ISSN)

  • 1097-2765

Language

  • eng

Conference Location

  • United States